Expression of cathepsin B and cystatin C in human breast cancer

被引：78

作者：

Yano, M

Hirai, K

Naito, Z

Yokoyama, M

Ishiwata, T

Shiraki, Y

Inokuchi, M

Asano, G

机构：

[1] Nippon Med Sch, Dept Pathol, Bunkyo Ku, Tokyo 1138602, Japan

[2] Nippon Med Sch, Dept Surg 2, Bunkyo Ku, Tokyo 1138602, Japan

[3] Mejiro 3rd Hosp, Dept Surg, Katsushika Ku, Tokyo 1250061, Japan

来源：

SURGERY TODAY | 2001年 / 31卷 / 05期

关键词：

cathepsin B; cystatin C; breast cancer;

D O I：

10.1007/s005950170126

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Cathepsin B, which was originally found to be a lysosomal cysteine protease, is also an important matrix protease. In this study, we investigated the expression of cathepsin B and cystatin C, the strongest inhibitor of cathepsin B, and measured the relative amounts of each in human breast cancer tissues. Cystatin C expression relative to cathepsin B expression was found to be decreased. This finding could be associated with the looseness of cancerous interstitial tissue, which might play a role in cancer invasion and metastasis. This report documents the first simultaneous investigation of cathepsin B and cystatin C in breast cancer tissues.

引用

页码：385 / 389

页数：5

共 30 条

[1] STRUCTURE AND EXPRESSION OF THE HUMAN CYSTATIN-C GENE [J].