Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

被引:56
作者
Montealegre, Sebastian [1 ,2 ,3 ]
van Endert, Peter M. [1 ,2 ,3 ]
机构
[1] INSERM, Unite 1151, Paris, France
[2] Univ Paris 05, Fac Med, Paris, France
[3] CNRS, UMR8253, Paris, France
来源
FRONTIERS IN IMMUNOLOGY | 2019年 / 9卷
关键词
major histocompatibility; endosome; dendritic cell; recycling; antigen presentation; cross-presentation; Arf6; Rab11; CROSS-PRESENTATION; OPEN CONFORMERS; INTRACELLULAR TRAFFICKING; TAPASIN DEPENDENCE; PEPTIDE EXCHANGE; QUALITY-CONTROL; CARGO PROTEINS; HLA-F; SURFACE; ARF6;
D O I
10.3389/fimmu.2018.03098
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8(+) T cells. Like other cell surface receptors, MHC class I molecules are continuously removed from the surface followed by intracellular degradation or recycling to the cell surface, in a process likely involving active quality control the mechanism of which remains unknown. The molecular players and pathways involved in internalization and recycling have previously been studied in model cell lines such as HeLa. However, dendritic cells (DCs), which rely on a specialized endocytic machinery that confers them the unique ability to "cross"-present antigens acquired by internalization, may use distinct MHC I recycling pathways and quality control mechanisms. By providing MHC I molecules cross-presenting antigens, these pathways may play an important role in one of the key functions of DCs, priming of T cell responses against pathogens and tumors. In this review, we will focus on endocytic recycling of MHC I molecules in various experimental conditions and cell types. We discuss the organization of the recycling pathway in model cell lines compared to DCs, highlighting the differences in the recycling rates and pathways of MHC I molecules between various cell types, and their putative functional consequences. Reviewing the literature, we find that conclusive evidence for significant recycling of MHC I molecules in primary DCs has yet to be demonstrated. We conclude that endocytic trafficking of MHC class I in DCs remains poorly understood and should be further studied because of its likely role in antigen cross-presentation.
引用
收藏
页数:11
相关论文
共 90 条
  • [1] F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins
    Abualrous, Esam T.
    Fritzsche, Susanne
    Hein, Zeynep
    Al-Balushi, Mohammed S.
    Reinink, Peter
    Boyle, Louise H.
    Wellbrock, Ursula
    Antoniou, Antony N.
    Springer, Sebastian
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (04) : 1248 - 1257
  • [2] Intracellular transport routes for MHC I and their relevance for antigen cross-presentation
    Adiko, Aime Cezaire
    Babdor, Joel
    Gutierrez-Martinez, Enric
    Guermonprez, Pierre
    Saveanu, Loredana
    [J]. FRONTIERS IN IMMUNOLOGY, 2015, 6
  • [3] The Connecdenn DENN Domain: A GEF for Rab35 Mediating Cargo-Specific Exit from Early Endosomes
    Allaire, Patrick D.
    Marat, Andrea L.
    Dall'Armi, Claudia
    Di Paolo, Gilbert
    McPherson, Peter S.
    Ritter, Brigitte
    [J]. MOLECULAR CELL, 2010, 37 (03) : 370 - 382
  • [4] Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens
    Alloatti, Andres
    Kotsias, Fiorella
    Pauwels, Anne-Marie
    Carpier, Jean-Marie
    Jouve, Mabel
    Timmerman, Evy
    Pace, Luigia
    Vargas, Pablo
    Maurin, Mathieu
    Gehrmann, Ulf
    Joannas, Leonel
    Vivar, Omar I.
    Lennon-Dumenil, Ana-Maria
    Savina, Ariel
    Gevaert, Kris
    Beyaert, Rudi
    Hoffmann, Eik
    Amigorena, Sebastian
    [J]. IMMUNITY, 2015, 43 (06) : 1087 - 1100
  • [5] Divide, Conquer, and Sense: CD8+CD28- T Cells in Perspective
    Arosa, Fernando A.
    Esgalhado, Andre J.
    Padrao, Carolina A.
    Cardoso, Elsa M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2017, 7
  • [6] Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I
    Arshad, Najla
    Cresswell, Peter
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (25) : 9555 - 9569
  • [7] IRAP+ endosomes restrict TLR9 activation and signaling
    Babdor, Joel
    Descamps, Delphyne
    Adiko, Aime Cezaire
    Tohme, Mira
    Maschalidi, Sophia
    Evnouchidou, Irini
    Vasconcellos, Luiz Ricardo
    De Luca, Mariacristina
    Mauvais, Francois-Xavier
    Garfa-Traore, Meriem
    Brinkmann, Melanie M.
    Chignard, Michel
    Manoury, Benedicte
    Saveanu, Loredana
    [J]. NATURE IMMUNOLOGY, 2017, 18 (05) : 509 - 518
  • [8] Structure of the human MHC-I peptide-loading complex
    Blees, Andreas
    Januliene, Dovile
    Hofmann, Tommy
    Koller, Nicole
    Schmidt, Carla
    Trowitzsch, Simon
    Moeller, Arne
    Tampe, Robert
    [J]. NATURE, 2017, 551 (7681) : 525 - +
  • [9] T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
    Boes, M
    Cerny, J
    Massol, R
    Op den Brouw, M
    Kirchhausen, T
    Chen, JZ
    Ploegh, HL
    [J]. NATURE, 2002, 418 (6901) : 983 - 988
  • [10] Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    Burgdorf, Sven
    Schoelz, Christian
    Kautz, Andreas
    Tampe, Robert
    Kurts, Christian
    [J]. NATURE IMMUNOLOGY, 2008, 9 (05) : 558 - 566