Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs

被引:9
作者
Martin Bellido, V. [1 ]
Vettorato, E. [1 ]
机构
[1] Dick White Referrals, Stn Farm, London Rd, Six Mile Bottom CB8 0UH, Cambridgeshire, England
关键词
TOTAL INTRAVENOUS ANESTHESIA; CONTINUOUS RATE INFUSIONS; CONSTANT RATE INFUSION; INTRAOCULAR-PRESSURE; LARYNGEAL MOTION; INTRAMUSCULAR ALFAXALONE; RECOVERY CHARACTERISTICS; PLASMA PHARMACOKINETICS; TILETAMINE-ZOLAZEPAM; KETAMINE-DIAZEPAM;
D O I
10.1111/jsap.13454
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
This clinical review summarises the pharmacological and anaesthetic properties of alfaxalone in the dog. Available pharmacokinetic-pharmacodynamic data and factors affecting the induction dose have been reported. Furthermore, quality of induction and recovery after alfaxalone administration, the use of alfaxalone for total intravenous anaesthesia, and its effects on the cardio-respiratory system, on laryngeal motion, on intraocular pressure and tear production have been evaluated. Finally, the use of alfaxalone in dogs undergoing caesarean section and the effect of intramuscular alfaxalone administration have been considered.
引用
收藏
页码:341 / 361
页数:21
相关论文
共 82 条
[1]  
Adetunji, 2021, BULGARIAN J VET MED
[2]   Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-β-cyclodextrin and propofol in dogs [J].
Ambros, Barbara ;
Duke-Novakovski, Tanya ;
Pasloske, Kirby S. .
AMERICAN JOURNAL OF VETERINARY RESEARCH, 2008, 69 (11) :1391-1398
[3]  
Ambros B, 2018, CAN VET J, V59, P791
[4]   An evaluation of anaesthetic induction in healthy dogs using rapid intravenous injection of propofol or alfaxalone [J].
Amengual, Maria ;
Flaherty, Derek ;
Auckburally, Adam ;
Bell, Andrew M. ;
Scott, E. Marian ;
Pawson, Patricia .
VETERINARY ANAESTHESIA AND ANALGESIA, 2013, 40 (02) :115-123
[5]   Sedative effects of two doses of alfaxalone in combination with methadone and a low dose of dexmedetomidine in healthy Beagles [J].
Arenillas, Mario ;
Aguado, Delia ;
Canfran, Susana ;
Lopez-Sanchez, Alejandro ;
de Segura, Ignacio A. Gomez .
VETERINARY ANAESTHESIA AND ANALGESIA, 2020, 47 (04) :463-471
[6]  
Bauer BS, 2016, CAN J VET RES, V80, P156
[7]   A controlled randomized clinical trial to assess postoperative analgesia after thiopental-isoflurane anaesthesia or total intravenous anaesthesia with alfaxalone in dogs [J].
Bennell, Paula M. ;
Whittem, Ted ;
Tudor, Elizabeth .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2019, 42 (03) :268-277
[8]   Effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone preventing movement in dogs [J].
Bennett, Katherine J. ;
Seddighi, Reza ;
Moorhead, Kaitlin A. ;
Messenger, Kristin ;
Cox, Sherry K. ;
Sun, Xiaocun ;
Pasloske, Kirby ;
Pypendop, Bruno H. ;
Doherty, Thomas J. .
VETERINARY ANAESTHESIA AND ANALGESIA, 2019, 46 (02) :173-181
[9]  
Bennett RC, 2017, AM J VET RES, V78, P956, DOI 10.2460/ajvr.78.8.956
[10]   Effect of rate of administration of propofol or alfaxalone on induction dose requirements and occurrence of apnea in dogs [J].
Bigby, Sarah E. ;
Beths, Thierry ;
Bauquier, Sebastien ;
Carter, Jennifer E. .
VETERINARY ANAESTHESIA AND ANALGESIA, 2017, 44 (06) :1267-1275