Mammalian gamete fertilization: sperm-zona pellucida interactions

被引：0

作者：

Finaz, C ^{[1
]}

Lefevre, A ^{[1
]}

机构：

[1] INSERM, Unite Maturat Gamet & Fecondat 355, F-92140 Clamart, France

来源：

CONTRACEPTION FERTILITE SEXUALITE | 1998年 / 26卷 / 7-8期

关键词：

gamete interaction; sperm proteins; zona pellucida; ligand; receptor; acrosome reaction;

D O I：

暂无

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Association of sperm with the acellular protective envelope of the oocyte, the zona pellucida, and their penetration is a determinant step in fertilization process, If is at this stage that species barriers take place to prevent cross fertilizations, This association is dependant upon binding of ZP3 oligosaccharides to specific sperm receptors, Their activation triggers the acrosome reaction via transduction pathways and release of proteolytic enzymes that dissociate the zona pellucida network, Then, secondary binding to zona pellucida components allows sperm to penetrate and cross the zona pellucida barrier, Several sperm surface proteins are putative receptors for zona pellucida partners, Repercussion of these studies on human fertility are discussed.

引用

页码：542 / 548

页数：7

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