Tp12 kinase signal transduction in inflammation and cancer

被引：75
作者：
Vougioukalaki, Maria
Kanellis, Dimitris C.
Gkouskou, Kalliopi
Eliopoulos, Aristides G. [1 ]
机构：
[1] Univ Crete, Sch Med, Div Basic Sci, Mol & Cellular Biol Lab, Iraklion, Crete, Greece
来源：
CANCER LETTERS | 2011年 / 304卷 / 02期
关键词：
Tp12; Cot kinase; MAP3K8; NF-kappa B1; tnip2; ABIN2; IKK beta; Inflammation; Cancer; NF-KAPPA-B; TUMOR PROGRESSION LOCUS-2; LPS-STIMULATED MACROPHAGES; GENE-EXPRESSION PATTERNS; TPL-2 MEK KINASE; T-CELL LINES; PROTEIN-KINASE; NF-KAPPA-B1; P105; MAP KINASE; REGULATED KINASE;
D O I：
10.1016/j.canlet.2011.02.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The activation of mitogen-activated protein kinases (MAPKs) is critically involved in inflammatory and oncogenic events. Tumor progression locus 2 (Tp12), also known as COT and MAP3 kinase 8 (MAP3K8), is a serine-threonine kinase with an important physiological role in tumor necrosis factor, interleukin-1, CD40, Toll-like receptor and G protein-coupled receptor-mediated ERK MAPK signaling. Whilst the full characterization of the biochemical events that lead to the activation of Tp12 still represent a major challenge, genetic and molecular evidence has highlighted interesting interactions with the NF-kappa B network. Here, we provide an overview of the multifaceted functions of Tp12 and the molecular mechanisms that govern its regulation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：80 / 89
页数：10
相关论文
共 85 条
[31]   The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-κB signaling downstream of TRAF2 [J].
Eliopoulos, AG ;
Davies, C ;
Blake, SSM ;
Murray, P ;
Najafipour, S ;
Tsichlis, PN ;
Young, LS .
JOURNAL OF VIROLOGY, 2002, 76 (09) :4567-4579
[32]   Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals [J].
Eliopoulos, AG ;
Dumitru, CD ;
Wang, CC ;
Cho, JH ;
Tsichlis, PN .
EMBO JOURNAL, 2002, 21 (18) :4831-4840
[33]  
Erny KM, 1996, ONCOGENE, V13, P2015
[34]   Inflammatory signaling pathways regulating ApoE gene expression in macrophages [J].
Gafencu, Anca V. ;
Robciuc, Marius R. ;
Fuior, Elena ;
Zannis, Vassilis I. ;
Kardassis, Dimitris ;
Simionescu, Maya .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (30) :21776-21785
[35]   The COOH-terminal domain of wild-type cot regulates its stability and kinase specific activity [J].
Gándara, ML ;
López, P ;
Hernando, R ;
Castaño, JG ;
Alemany, S .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) :7377-7390
[36]   Cot/Tp12 and PKC cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain [J].
Gomez-Casero, Elena ;
San-Antonio, Belen ;
Iniguez, Miguel A. ;
Fresno, Manuel .
CELLULAR SIGNALLING, 2007, 19 (08) :1652-1661
[37]   Pharmacologic inhibition of Tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood* [J].
Hall, J. Perry ;
Kurdi, Yahya ;
Hsu, Sang ;
Cuozzo, John ;
Liu, Julie ;
Telliez, Jean-Baptiste ;
Seidl, Katherine J. ;
Winkler, Aaron ;
Hu, Yonghan ;
Green, Neal ;
Askew, G. Roger ;
Tam, Steve ;
Clark, James D. ;
Lin, Lih-Ling .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) :33295-33304
[38]   Proteinase-activated receptor-1 - Triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration [J].
Hatziapostolou, Maria ;
Polytarchou, Christos ;
Panutsopulos, Dimitrios ;
Covic, Lidija ;
Tsichlis, Philip N. .
CANCER RESEARCH, 2008, 68 (06) :1851-1861
[39]  
HIRATA K, 2002, BIOL PHARM BULL, V33, P133
[40]   Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal-Regulated Kinase Activation and Lipolysis [J].
Jager, Jennifer ;
Gremeaux, Thierry ;
Gonzalez, Teresa ;
Bonnafous, Stephanie ;
Debard, Cyrille ;
Laville, Martine ;
Vidal, Hubert ;
Tran, Albert ;
Gual, Philippe ;
Le Marchand-Brustel, Yannick ;
Cormont, Mireille ;
Tanti, Jean-Francois .
DIABETES, 2010, 59 (01) :61-70
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