Tp12 kinase signal transduction in inflammation and cancer

被引：75
作者：
Vougioukalaki, Maria
Kanellis, Dimitris C.
Gkouskou, Kalliopi
Eliopoulos, Aristides G. [1 ]
机构：
[1] Univ Crete, Sch Med, Div Basic Sci, Mol & Cellular Biol Lab, Iraklion, Crete, Greece
来源：
CANCER LETTERS | 2011年 / 304卷 / 02期
关键词：
Tp12; Cot kinase; MAP3K8; NF-kappa B1; tnip2; ABIN2; IKK beta; Inflammation; Cancer; NF-KAPPA-B; TUMOR PROGRESSION LOCUS-2; LPS-STIMULATED MACROPHAGES; GENE-EXPRESSION PATTERNS; TPL-2 MEK KINASE; T-CELL LINES; PROTEIN-KINASE; NF-KAPPA-B1; P105; MAP KINASE; REGULATED KINASE;
D O I：
10.1016/j.canlet.2011.02.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The activation of mitogen-activated protein kinases (MAPKs) is critically involved in inflammatory and oncogenic events. Tumor progression locus 2 (Tp12), also known as COT and MAP3 kinase 8 (MAP3K8), is a serine-threonine kinase with an important physiological role in tumor necrosis factor, interleukin-1, CD40, Toll-like receptor and G protein-coupled receptor-mediated ERK MAPK signaling. Whilst the full characterization of the biochemical events that lead to the activation of Tp12 still represent a major challenge, genetic and molecular evidence has highlighted interesting interactions with the NF-kappa B network. Here, we provide an overview of the multifaceted functions of Tp12 and the molecular mechanisms that govern its regulation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：80 / 89
页数：10
相关论文
共 85 条
[1]   Clinically relevant end points and new drug approvals for myeloma [J].
Anderson, K. C. ;
Kyle, R. A. ;
Rajkumar, S. V. ;
Stewart, A. K. ;
Weber, D. ;
Richardson, P. .
LEUKEMIA, 2008, 22 (02) :231-239
[2]  
[Anonymous], SCI STKE, DOI DOI 10.1126/STKE.3572006RE13
[3]   Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells [J].
Babu, Geetha ;
Waterfield, Michael ;
Chang, Mikyoung ;
Wu, Xuefeng ;
Sun, Shao-Cong .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (20) :14041-14047
[4]   Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2:: Implications for a novel mechanism of Tpl2 regulation [J].
Babu, GR ;
Jin, W ;
Norman, L ;
Waterfield, M ;
Chang, MY ;
Wu, XF ;
Zhang, MY ;
Sun, SC .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763 (02) :174-181
[5]   Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells [J].
Banerjee, A ;
Gugasyan, R ;
McMahon, M ;
Gerondakis, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3274-3279
[6]   NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms [J].
Banerjee, Ashish ;
Grumont, Raelene ;
Gugasyan, Raffi ;
White, Christine ;
Strasser, Andreas ;
Gerondakis, Steve .
BLOOD, 2008, 112 (13) :5063-5073
[7]   Reverse engineering of regulatory networks in human B cells [J].
Basso, K ;
Margolin, AA ;
Stolovitzky, G ;
Klein, U ;
Dalla-Favera, R ;
Califano, A .
NATURE GENETICS, 2005, 37 (04) :382-390
[8]   Gene-expression profiles predict survival of patients with lung adenocarcinoma [J].
Beer, DG ;
Kardia, SLR ;
Huang, CC ;
Giordano, TJ ;
Levin, AM ;
Misek, DE ;
Lin, L ;
Chen, GA ;
Gharib, TG ;
Thomas, DG ;
Lizyness, ML ;
Kuick, R ;
Hayasaka, S ;
Taylor, JMG ;
Iannettoni, MD ;
Orringer, MB ;
Hanash, S .
NATURE MEDICINE, 2002, 8 (08) :816-824
[9]   Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105 [J].
Beinke, S ;
Robinson, MJ ;
Hugunin, M ;
Ley, SC .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (21) :9658-9667
[10]   NF-κB1 p105 negatively regulates TPL-2 MEK kinase activity [J].
Beinke, S ;
Deka, J ;
Lang, V ;
Belich, MP ;
Walker, PA ;
Howell, S ;
Smerdon, SJ ;
Gamblin, SJ ;
Ley, SC .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (14) :4739-4752
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