Stachylines A-D from the Sponge-Derived Fungus Stachylidium sp.

被引：44

作者：

Almeida, Celso ^{[1
]}

Part, Natalja ^{[1
]}

Bouhired, Sarah ^{[1
]}

Kehraus, Stefan ^{[1
]}

Koenig, Gabriele M. ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut Biol, D-53115 Bonn, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 01期

关键词：

ACTIVE SECONDARY METABOLITES; NATURAL-PRODUCTS; NOCARDICIN-A; ACID; BIOSYNTHESIS; ASSAY; INHIBITION; TYROSINE; OXIME; NOCL;

D O I：

10.1021/np1005345

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.

引用

页码：21 / 25

页数：5

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