RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events

被引：107

作者：

Delanghe, Tom ^{[1
,2
]}

Dondelinger, Yves ^{[1
,2
]}

Bertrand, Mathieu J. M. ^{[1
,2
]}

机构：

[1] VIB Ctr Inflammat Res, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

来源：

TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 03期

关键词：

NF-KAPPA-B; CELL-DEATH; CATALYTIC SUBUNIT; NECROPTOSIS; INFLAMMATION; ACTIVATION; APOPTOSIS; UBIQUITINATION; MUTATIONS; NECROSIS;

D O I：

10.1016/j.tcb.2019.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead as an active kinase to promote the killing of the cell. While RIPK1 kinase-dependent cell death has revealed its physiological importance in the context of microbial infection, aberrant activation of RIPK1 is also demonstrated to promote cell death-driven inflammatory pathologies, highlighting the importance of fundamentally understanding proper RIPK1 regulation. Recent advances in the field demonstrated the crucial role of phosphorylation in the fine-tuning of RIPK1 activation and, additionally, question the exact mechanism by which RIPK1 enzymatic activity transmits the death signal.

引用

页码：189 / 200

页数：12

共 69 条

[1] Activation loop phosphorylation and catalysis in protein kinases: Is there functional evidence for the autoinhibitor model? [J].

Adams, JA .

BIOCHEMISTRY, 2003, 42 (03) :601-607

[2] Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2 [J].

Annibaldi, Alessandro ;

John, Sidonie Wicky ;

Berghe, Tom Vanden ;

Swatek, Kirby N. ;

Ruan, Jianbin ;

Liccardi, Gianmaria ;

Bianchi, Katiuscia ;

Elliott, Paul R. ;

Choi, Sze Men ;

Van Coillie, Samya ;

Bertin, John ;

Wu, Hao ;

Komander, David ;

Vandenabeele, Peter ;

Silke, John ;

Meier, Pascal .

MOLECULAR CELL, 2018, 69 (04) :566-+

[3] Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer [J].

Annibaldi, Alessandro ;

Meier, Pascal .

TRENDS IN MOLECULAR MEDICINE, 2018, 24 (01) :49-65

[4] Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice [J].

Berger, Scott B. ;

Kasparcova, Viera ;

Hoffman, Sandy ;

Swift, Barb ;

Dare, Lauren ;

Schaeffer, Michelle ;

Capriotti, Carol ;

Cook, Michael ;

Finger, Joshua ;

Hughes-Earle, Angela ;

Harris, Philip A. ;

Kaiser, William J. ;

Mocarski, Edward S. ;

Bertin, John ;

Gough, Peter J. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (12) :5476-5480

[5] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[6] NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis [J].

Boutaffala, L. ;

Bertrand, M. J. M. ;

Remouchamps, C. ;

Seleznik, G. ;

Reisinger, F. ;

Janas, M. ;

Benezech, C. ;

Fernandes, M. T. ;

Marchetti, S. ;

Mair, F. ;

Ganeff, C. ;

Hupalowska, A. ;

Ricci, J-E ;

Becher, B. ;

Piette, J. ;

Knolle, P. ;

Caamano, J. ;

Vandenabeele, P. ;

Heikenwalder, M. ;

Dejardin, E. .

CELL DEATH AND DIFFERENTIATION, 2015, 22 (12) :2020-2033

[7] Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation [J].

Cuchet-Lourenco, Delphine ;

Eletto, Davide ;

Wu, Changxin ;

Plagnol, Vincent ;

Papapietro, Olivier ;

Curtis, James ;

Ceron-Gutierrez, Lourdes ;

Bacon, Chris M. ;

Hackett, Scott ;

Alsaleem, Badr ;

Maes, Mailis ;

Gaspar, Miguel ;

Alisaac, Ali ;

Goss, Emma ;

AlIdrissi, Eman ;

Siegmund, Daniela ;

Wajant, Harald ;

Kumararatne, Dinakantha ;

AlZahrani, Mofareh S. ;

Arkwright, Peter D. ;

Abinun, Mario ;

Doffinger, Rainer ;

Nejentsev, Sergey .

SCIENCE, 2018, 361 (6404) :810-813

[8] Identification of RIP1 kinase as a specific cellular target of necrostatins [J].

Degterev, Alexei ;

Hitomi, Junichi ;

Germscheid, Megan ;

Ch'en, Irene L. ;

Korkina, Olga ;

Teng, Xin ;

Abbott, Derek ;

Cuny, Gregory D. ;

Yuan, Chengye ;

Wagner, Gerhard ;

Hedrick, Stephen M. ;

Gerber, Scott A. ;

Lugovskoy, Alexey ;

Yuan, Junying .

NATURE CHEMICAL BIOLOGY, 2008, 4 (05) :313-321

[9] Targeting RIPK1 for the treatment of human diseases [J].

Degterev, Alexei ;

Ofengeim, Dimitry ;

Yuan, Junying .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (20) :9714-9722

[10] RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition [J].

Dondelinger, Y. ;

Aguileta, M. A. ;

Goossens, V. ;

Dubuisson, C. ;

Grootjans, S. ;

Dejardin, E. ;

Vandenabeele, P. ;

Bertrand, M. J. M. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (10) :1381-1392

← 1 2 3 4 5 6 7 →