Iron-catalyzed alkynylation of tertiary aliphatic amines with 1-iodoalkynes to synthesize propargylamines

被引：13
作者：
Ma, Lina [1 ,2 ,3 ]
Shi, Xiaolin [1 ,2 ,3 ]
Li, Xiaowei [1 ,2 ,3 ]
Shi, Dayong [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 24期
基金：
中国国家自然科学基金;
关键词：
H BONDS ADJACENT; HOMOLYTIC AROMATIC SUBSTITUTION; ONE-POT SYNTHESIS; TERMINAL ALKYNES; ENANTIOSELECTIVE SYNTHESIS; COPPER NANOPARTICLES; OXIDATIVE AMIDATION; SECONDARY-AMINES; EFFICIENT; ALDEHYDES;
D O I：
10.1039/c8qo01028e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method of alkynylation of tertiary aliphatic amines with 1-iodoalkynes has been developed in the presence of FeCl2 as a catalyst and tert-butyl hydroperoxide as an oxidant. With this method, a variety of propargylamines were obtained in good to excellent yields from inexpensive and readily available reagents. The studies on the possible reaction pathway suggest that this reaction proceeds through a radical process.
引用
收藏
页码：3515 / 3519
页数：5
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