Key Regulators of Autophagosome Closure

被引：26

作者：

Jiang, Wenyan ^{[1
]}

Chen, Xuechai ^{[1
]}

Ji, Cuicui ^{[1
]}

Zhang, Wenting ^{[1
]}

Song, Jianing ^{[1
]}

Li, Jie ^{[2
]}

Wang, Juan ^{[1
]}

机构：

[1] Beijing Univ Technol, Ctr Excellence Environm Safety & Biol Effects, Fac Environm & Life Sci, Beijing Int Sci & Technol Cooperat Base Antiviral, 100 Ping Le Yuan, Beijing 100124, Peoples R China

[2] Chinese Acad Fishery Sci, Lab Marine Fisheries & Aquaculture, Qingdao Natl Lab Marine Sci & Technol,Yellow Sea, Key Lab Maricultural Organism Dis Control,Minist, Qingdao 266071, Peoples R China

来源：

CELLS | 2021年 / 10卷 / 11期

基金：

中国国家自然科学基金;

关键词：

autophagy; autophagosome; closure; isolation membrane; SELECTIVE AUTOPHAGY; MEMBRANE-FUSION; PROTEINS; TRANSPORT; LIPIDATION; MECHANISMS; CYTOPLASM; COMPLEX; SNARES; LC3;

D O I：

10.3390/cells10112814

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.

引用

页数：13

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