Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases

被引:5
作者
Okamura, Takeshi [1 ]
Izumo, Toshiyuki [2 ]
Yagishita, Hisao [3 ]
Mori, Taisuke [4 ]
Sakamoto, Kei [5 ]
Harada, Kiyoshi [1 ]
机构
[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Maxillofacial Surg, Tokyo, Japan
[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Diagnost Oral Pathol, Tokyo, Japan
[3] Nippon Dent Univ Hosp, Div Oral Diag Dent & Maxillofacial Radiol & Oral, Tokyo, Japan
[4] Natl Canc Ctr, Dept Clin Lab & Pathol, Tokyo, Japan
[5] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Oral Pathol, Tokyo, Japan
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2016年 / 122卷 / 03期
关键词
TUBULAR TUMORS; CARCINOMA; ABNORMALITY; DIAGNOSIS; ADENOMAS; STOMACH; LAYER;
D O I
10.1016/j.oooo.2016.05.005
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective. The aim of this study was to assess objectively the predictive value of the atypical appearance of the basal layer of oral epithelial dysplasia (OED) for development into invasive carcinoma. Study Design. Ninety-six OED cases were examined. These cases were divided into 2 groups: 38 cases that developed into invasive carcinoma and 58 cases that did not. Furthermore, 12 histopathological factors were quantified morphometrically in each case and assessed by Cox's proportional hazards model. Results. The standard deviation of the length between the apical membrane of the basal cells and the basement membrane was significantly associated with development of OED into invasive carcinoma (P <.001; hazard ratio, 3.124). Conclusion. We provided novel, objective data demonstrating that an atypical appearance, especially the disordered arrangement of the basal cells representing loss of polarity, may be useful for predicting the development of OED into invasive carcinoma of the tongue.
引用
收藏
页码:355 / 361
页数:7
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