T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK

被引：41

作者：

Dadgostar, H

Doyle, SE

Shahangian, A

Garcia, DE

Cheng, GH ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Med Sci Training Program, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

来源：

FEBS LETTERS | 2003年 / 553卷 / 03期

关键词：

tumor necrosis factor receptor-associated factor 3; tumor necrosis factor receptor; jun N-terminal kinase; nuclear factor kappa B; subcellular localization; signal transduction;

D O I：

10.1016/S0014-5793(03)01072-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：403 / 407

页数：5

共 23 条

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