Crosstalk in cancer resistance and metastasis

被引：60

作者：

Norouzi, Saeed ^{[1
]}

Valokala, Mahmoud Gorgi ^{[2
]}

Mosaffa, Fatemeh ^{[1
,3
]}

Zirak, Mohammad Reza ^{[2
]}

Zamani, Parvin ^{[4
]}

Behravan, Javad ^{[1
,5
,6
]}

机构：

[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamy & Toxicol, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Student Res Comm, Mashhad, Iran

[5] Mediphage Bioceut Inc, MaRS Ctr, 661 Univ Ave,Suite 1300,West Tower, Toronto, ON, Canada

[6] Univ Waterloo, Sch Pharm, 200 Univ Ave W, Waterloo, ON, Canada

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 132卷

关键词：

Cancer; Chemotherapy; Resistance; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; MATRIX METALLOPROTEINASE INDUCER; TUMOR-CELL INVASION; BREAST-CANCER; MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; DRUG-RESISTANCE; TERMINAL HYDROLASE; MDR1; EXPRESSION; PROMOTES PROLIFERATION;

D O I：

10.1016/j.critrevonc.2018.09.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The main obstacles that lead to clinical failure in cancer treatment are the development of resistant to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to prolonged chemotherapeutic processes. Recent studies have revealed some evidence about the existence of a direct relationship between development of drug resistance and triggering of invasive capability in tumor cells. Therefore, devising and application of chemotherapeutic procedures that are not prone to the development of chemotherapy resistance are necessary. Here, we focus on CD147, CD44, ANAX2, P-gp, MMPs, and UCH-L1 proteins involved in the crosstalk between metastasis and cancer treatment. We think that further structural and functional analysis of these proteins may direct scientists towards designing highly effective chemotherapy procedures.

引用

页码：145 / 153

页数：9

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