The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction

被引：73
作者：
Schlegel, A
Lisanti, MP
机构：
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Albert Einstein Comprehens Canc Ctr, Bronx, NY 10461 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2001年 / 12卷 / 01期
关键词：
caveolin; caveolae; signal transduction; cancer; muscular dystrophy;
D O I：
10.1016/S1359-6101(00)00022-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：41 / 51
页数：11
相关论文
共 98 条
  • [1] POTOCYTOSIS - SEQUESTRATION AND TRANSPORT OF SMALL MOLECULES BY CAVEOLAE
    ANDERSON, RGW
    KAMEN, BA
    ROTHBERG, KG
    LACEY, SW
    [J]. SCIENCE, 1992, 255 (5043) : 410 - 411
  • [2] Membrane binding of peptides containing both basic and aromatic residues.: Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS
    Arbuzova, A
    Wang, LB
    Wang, JY
    Hangyás-Mihályné, G
    Murray, D
    Honig, B
    McLaughlin, S
    [J]. BIOCHEMISTRY, 2000, 39 (33) : 10330 - 10339
  • [3] ATSHAVES BP, 2000, IN PRESS J BIOL CHEM
  • [4] Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae
    Babitt, J
    Trigatti, B
    Rigotti, A
    Smart, EJ
    Anderson, RGW
    Xu, SZ
    Krieger, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (20) : 13242 - 13249
  • [5] Functions of lipid rafts in biological membranes
    Brown, DA
    London, E
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 : 111 - 136
  • [6] Mutation in the CAV3 gene causes partial caveolin-3 deficiency and hyperCKemia
    Carbone, I
    Bruno, C
    Sotgia, F
    Bado, M
    Broda, P
    Masetti, E
    Panella, A
    Zara, F
    Bricarelli, FD
    Cordone, G
    Lisanti, MP
    Minetti, C
    [J]. NEUROLOGY, 2000, 54 (06) : 1373 - 1376
  • [7] PURIFICATION AND CHARACTERIZATION OF SMOOTH-MUSCLE CELL CAVEOLAE
    CHANG, WJ
    YING, YS
    ROTHBERG, KG
    HOOPER, NM
    TURNER, AJ
    GAMBLIEL, HA
    DEGUNZBURG, J
    MUMBY, SM
    GILMAN, AG
    ANDERSON, RGW
    [J]. JOURNAL OF CELL BIOLOGY, 1994, 126 (01) : 127 - 138
  • [8] Chapman HA, 1999, THROMB HAEMOSTASIS, V82, P291
  • [9] SIGNAL-TRANSDUCTION OF A G-PROTEIN-COUPLED RECEPTOR IN CAVEOLAE - COLOCALIZATION OF ENDOTHELIN AND ITS RECEPTOR WITH CAVEOLIN
    CHUN, MY
    LIYANAGE, UK
    LISANTI, MP
    LODISH, HF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) : 11728 - 11732
  • [10] CAVEOLIN CYCLES BETWEEN PLASMA-MEMBRANE CAVEOLAE AND THE GOLGI-COMPLEX BY MICROTUBULE-DEPENDENT AND MICROTUBULE-INDEPENDENT STEPS
    CONRAD, PA
    SMART, EJ
    YING, YS
    ANDERSON, RGW
    BLOOM, GS
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 131 (06) : 1421 - 1433
12345678910