Elaboration of laboratory strains of Ebola virus and study of pathophysiological reactions of animals inoculated with these strains

被引：9
作者：
Chepurnov, AA [1 ]
Zubavichene, NM [1 ]
Dadaeva, AA [1 ]
机构：
[1] State Res Ctr Virol & Biotechnol, Novosibirsk 630559, Russia
来源：
ACTA TROPICA | 2003年 / 87卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
Ebola virus; adaptation; variants; pathogenesis;
D O I：
10.1016/S0001-706X(03)00122-0
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Selective passages in animals and cell cultures were used to produce a set of Ebola virus (EBO) laboratory strains with changed virulence for some animal genera. Comparative study of the genomes of wild-type EBO and selected variants formed the basis for studying the molecular causes of EBO virulence. Investigation of pathophysiological reactions of the animals inoculated with these strains allowed some key factors in Ebola fever pathogenesis to be determined. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：321 / 329
页数：9
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