MR imaging probes: design and applications

被引：121

作者：

Boros, Eszter

Gale, Eric M.

Caravan, Peter ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

HUMAN SERUM-ALBUMIN; AORTOILIAC OCCLUSIVE DISEASE; ANGIOGRAPHY CONTRAST AGENT; SATURATION-TRANSFER CEST; WATER EXCHANGE-RATE; HIGH-RELAXIVITY; PROTEIN-BINDING; GADOLINIUM COMPLEX; GD3+ COMPLEXES; ENHANCED MRI;

D O I：

10.1039/c4dt02958e

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This perspective outlines strategies towards the development of MR imaging probes that our lab has explored over the last 15 years. Namely, we discuss methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment.

引用

收藏

页码：4804 / 4818

页数：15

相关论文

共 158 条

[81] Activation and Retention: A Magnetic Resonance Probe for the Detection of Acute Thrombosis [J].

Loving, Galen S. ;

Caravan, Peter .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (04) :1140-1143

[82] Redox-Activated Manganese-Based MR Contrast Agent [J].

Loving, Galen S. ;

Mukherjee, Shreya ;

Caravan, Peter .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (12) :4620-4623

[83] pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation [J].

Lowe, MP ;

Parker, D ;

Reany, O ;

Aime, S ;

Botta, M ;

Castellano, G ;

Gianolio, E ;

Pagliarin, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (31) :7601-7609

[84] Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent [J].

Lubag, Angelo J. M. ;

De Leon-Rodriguez, Luis M. ;

Burgess, Shawn C. ;

Sherry, A. Dean .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (45) :18400-18405

[85] Bioresponsive, Cell-Penetrating, and Multimeric MR Contrast Agents [J].

Major, Jody L. ;

Meade, Thomas J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (07) :893-903

[86] Mechanisms of ZnII-Activated Magnetic Resonance Imaging Agents [J].

Major, Jody L. ;

Boiteau, Rene M. ;

Meade, Thomas J. .

INORGANIC CHEMISTRY, 2008, 47 (22) :10788-10795

[87] Analytical Methods for Characterizing Magnetic Resonance Probes [J].

Manus, Lisa M. ;

Strauch, Renee C. ;

Hung, Andy H. ;

Eckermann, Amanda L. ;

Meade, Thomas J. .

ANALYTICAL CHEMISTRY, 2012, 84 (15) :6278-6287

[88] The effect of a phosphodiester linking group on albumin binding, blood half-life, and relaxivity of intravascular diethylenetriaminepentaacetato aquo gadolinium(III) MRI contrast agents [J].

McMurry, TJ ;

Parmelee, DJ ;

Sajiki, H ;

Scott, DM ;

Ouellet, HS ;

Walovitch, RC ;

Tyeklár, Z ;

Dumas, S ;

Bernard, P ;

Nadler, S ;

Midelfort, K ;

Greenfield, M ;

Troughton, J ;

Lauffer, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (16) :3465-3474

[89]

Merbach A. S., 2013, The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

[90] A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding [J].

Messeri, D ;

Lowe, MP ;

Parker, D ;

Botta, M .

CHEMICAL COMMUNICATIONS, 2001, (24) :2742-2743

← 4 5 6 7 8 9 10 11 12 13 →