ENHANCED EXCITATORY AND REDUCED INHIBITORY SYNAPTIC TRANSMISSION CONTRIBUTE TO PERSISTENT PAIN-INDUCED NEURONAL HYPER-RESPONSIVENESS IN ANTERIOR CINGULATE CORTEX

被引:41
作者
Gong, K-R [3 ]
Cao, F-L [1 ,2 ]
He, Y. [3 ]
Gao, C-Y [3 ]
Wang, D-D [3 ]
Li, H. [3 ]
Zhang, F-K [3 ]
An, Y-Y [3 ]
Lin, Q. [4 ]
Chen, J. [1 ,2 ,3 ]
机构
[1] Fourth Mil Med Univ, Inst Biomed Sci Pain, Tangdu Hosp, Xian 710038, Peoples R China
[2] Fourth Mil Med Univ, Inst Funct Brain Disorders, Tangdu Hosp, Xian 710038, Peoples R China
[3] Capital Med Univ, Inst Biomed Sci Pain, Beijing 100069, Peoples R China
[4] Univ Texas Arlington, Coll Sci, Dept Psychol, Arlington, TX 76019 USA
关键词
persistent nociception; anterior cingulate cortex; sEPSC; sIPSC mEPSC; mIPSC; MEDIAL PREFRONTAL CORTEX; SUPERFICIAL DORSAL-HORN; BEE VENOM INJECTION; GABAERGIC INHIBITION; NEUROPATHIC PAIN; NOCICEPTIVE NEURONS; PYRAMIDAL NEURONS; CONSCIOUS RAT; SCIATIC-NERVE; HUMAN BRAIN;
D O I
10.1016/j.neuroscience.2010.10.028
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective dimension of pain Although much evidence has pointed to an increased excitatory synaptic transmission in the ACC in some of the pathological pain state, the inhibitory synaptic transmission in this process has not been well studied Also, the overall changes of excitatory and inhibitory synaptic transmission have not been comparatively studied in an animal model displaying both long term persistent nociception and hyperalgesia Here we used patch clamp recordings in ACC brain slices to observe the changes in synaptic transmission in a pain model induced by peripheral bee venom injection First, we show that, comparing with those of naive and saline controlled rats, there was a significant increase in spike frequency in ACC neurons harvested from rats after 2 h period of peripheral persistent painful stimuli Second, it is further shown that the frequency, amplitude and half width were all increased in spontaneous excitatory post synaptic currents (sEPSCs) while the amplitude of spontaneous inhibitory post-synaptic currents (sIPSCs) was decreased The recordings of miniature post synaptic currents demonstrate an increase in frequency of miniature excitatory post-synaptic currents (mEPSCs) and a decrease in both frequency and amplitude of miniature inhibitory post synaptic currents (mIPSCs) in rats' ACC slice of bee venom treatment Taken together, the present results demonstrate an unparalleled change between excitatory and inhibitory synaptic transmission in the ACC under a state of peripheral persistent nociception that might be underlying mechanisms of the excessive excitability of the ACC neurons We propose that the painful stimuli when lasts or becomes persistent may cause a disruption of the balance between excitatory and inhibitory synaptic transmission that can contribute to the functional change in the ACC (C) 2010 IBRO Published by Elsevier Ltd All rights reserved
引用
收藏
页码:1314 / 1325
页数:12
相关论文
共 80 条
[61]   Altered synaptic transmission in rat anterior cingulate cortex following peripheral nerve injury [J].
Tachibana, Kaori ;
Kato, Rui ;
Tsuruga, Kenkichi ;
Takita, Koichi ;
Hashimoto, Toshikazu ;
Morimoto, Yuji .
BRAIN RESEARCH, 2008, 1238 :53-58
[62]   Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing [J].
Tan, Andrew M. ;
Choi, Jin-Sung ;
Waxman, Stephen G. ;
Hains, Bryan C. .
JOURNAL OF NEUROPHYSIOLOGY, 2009, 102 (04) :2396-2409
[63]   Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain [J].
Toyoda, Hiroki ;
Zhao, Ming-Gao ;
Zhuo, Min .
MOLECULAR PAIN, 2009, 5
[64]   Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex [J].
Trantham-Davidson, H ;
Neely, LC ;
Lavin, A ;
Seamans, JK .
JOURNAL OF NEUROSCIENCE, 2004, 24 (47) :10652-10659
[65]   Differential projections from the mediodorsal and centrolateral thalamic nuclei to the frontal cortex in rats [J].
Wang, CC ;
Shyu, BC .
BRAIN RESEARCH, 2004, 995 (02) :226-235
[66]   Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat [J].
Wei, F ;
Zhuo, M .
JOURNAL OF PHYSIOLOGY-LONDON, 2001, 532 (03) :823-833
[67]   Imbalance towards inhibition as a substrate of aging-associated cognitive impairment [J].
Wong, TP ;
Marchese, G ;
Casu, MA ;
Ribeiro-da-Silva, A ;
Cuello, AC ;
De Koninck, Y .
NEUROSCIENCE LETTERS, 2006, 397 (1-2) :64-68
[68]   Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex [J].
Wu, Long-Jun ;
Steenland, Hendrik W. ;
Kim, Susan S. ;
Isiegas, Carolina ;
Abel, Ted ;
Kaang, Bong-Kiun ;
Zhuo, Min .
MOLECULAR PAIN, 2008, 4
[69]   A RISE IN POSTSYNAPTIC CA2+ POTENTIATES MINIATURE EXCITATORY POSTSYNAPTIC CURRENTS AND AMPA RESPONSES IN HIPPOCAMPAL-NEURONS [J].
WYLLIE, DJA ;
MANABE, T ;
NICOLL, RA .
NEURON, 1994, 12 (01) :127-138
[70]   Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex [J].
Xu, Hui ;
Wu, Long-Jun ;
Wang, Hansen ;
Zhang, Xuehan ;
Vadakkan, Kunjumon I. ;
Kim, Susan S. ;
Steenland, Hendrik W. ;
Zhuo, Min .
JOURNAL OF NEUROSCIENCE, 2008, 28 (29) :7445-7453