Synthesis of gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols isolated from Piper gibbilimbum

被引：9

作者：

Abe, Y

Takikawa, H

Mori, K

机构：

[1] Sci Univ Tokyo, Grad Sch Sci, Dept Math & Sci Educ, Shinjuku Ku, Tokyo 1628601, Japan

[2] Sci Univ Tokyo, Fac Sci, Dept Chem, Shinjuku Ku, Tokyo 1628601, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 03期

关键词：

alkenyl phenols; antibacterial activity; cytotoxic activity; Piper gibbilimbum;

D O I：

10.1271/bbb.65.732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gibbilimbols A [(E)-4-(4-decenyl)phenol, 1], B [(E)-4(3-decenyl)phenol, 2], C [(E)-4-(4-octenyl)phenol, 3] and D [(E)-4-(3-octenyl)phenol, 4] mere synthesized by coupling the phenolic parts with the alkyne parts and then reducing the triple bond of the resulting alkynylphenols, These alkenylphenols (1-4) are the cytotoxic and antibacterial constituents of the leaves of a medicinal plant (Piper gibbilimbum) that is used as a traditional medicine in Papua New Guinea.

引用

页码：732 / 735

页数：4

共 6 条

[1] STUDIES ON THE SYNTHESIS OF APHIDICOLIN - PREPARATION OF AROMATIC PRECURSORS FOR SPIROCYCLIC DIENONE FORMATION [J].