Household Infrared Technology as an Energy-Efficient Approach to Achieve C-Cπ Bond Construction Reactions

We examined the ability of short-wave infrared (IR) light in the lambda(1.5-3.0 mu m) region of the infrared emission spectrum to accomplish C-C pi bond construction reaction between pi-excessive azaheteroaromatic and different carbonyl substrates supported on a bentonitic clay catalyst in solventless condition via a three-component condensation reaction. Preliminary studies show that the implementation of a domestic Flavor-Wave (R) oven fitted with a halogen heater lamp as a chemical reactor was as effective as the use of near IR light (lambda(1.1 mu m)) in fostering batch-wise organic reactions. Overall, this approach reveals its potential exploitation as an energy-efficient source to assemble biologically engaging (hetero)arenebisindolylmethanes framework, in the same way, that assure its sustainable development as for efficient generation of small libraries of molecules comparable to high-tech instrumentations performances.