A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities

被引：124

作者：

Hida, K

Klagsbrun, N

机构：

[1] Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Surg, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

来源：

CANCER RESEARCH | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1158/0008-5472.CAN-05-0002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

it has been shown that endothelial cells in solid tumors are cytogenetically abnormal. These cells are aneuploid with multiple chromosomes and multiple centrosomes. Unlike normal endothetial cells which remain diploid in long-term culture, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells are inherently unstable. It is speculated that this instability might compromise the effectiveness of antiangiogenesis therapy.

引用

页码：2507 / 2510

页数：4

共 20 条

[1] Murine lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro [J].