Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease

被引：337

作者：

Zhang, Ming ^{[1
]}

Sun, Kaiji ^{[1
]}

Wu, Yujun ^{[1
]}

Yang, Ying ^{[1
]}

Tso, Patrick ^{[2
]}

Wu, Zhenlong ^{[1
,3
]}

机构：

[1] China Agr Univ, Dept Anim Nutr & Feed Sci, State Key Lab Anim Nutr, Beijing, Peoples R China

[2] Univ Cincinnati, Dept Pathol & Lab Med, Metab Dis Inst, Cincinnati, OH USA

[3] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

基金：

中国国家自然科学基金;

关键词：

intestinal microbiota; host immune response; inflammatory bowel disease; intestinal barrier function; epithelial cells; ARYL-HYDROCARBON RECEPTOR; DISTAL ULCERATIVE-COLITIS; CROHNS-DISEASE; GUT MICROBIOTA; COLONIC-MUCOSA; COMMENSAL MICROBIOTA; ESCHERICHIA-COLI; ILEAL MUCOSA; WESTERN DIET; RISK-FACTORS;

D O I：

10.3389/fimmu.2017.00942

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic susceptibility and environmental factors are implicated in the initiation and progression of IBD. Recent studies with experimental animal models and clinical patients indicated that the intestinal microbiota is one of the critical environmental factors that influence nutrient metabolism, immune responses, and the health of the host in various intestinal diseases, including ulcerative colitis and Crohn's disease. The objective of this review is to highlight the crosstalk between gut microbiota and host immune response and the contribution of this interaction to the pathogenesis of IBD. In addition, potential therapeutic strategies targeting the intestinal micro-ecosystem in IBD are discussed.

引用

页码：1 / 13

页数：13

共 187 条

[51] Towards personalized care in IBD [J].

Gerich, Mark E. ;

McGovern, Dermot P. B. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (05) :287-299

[52] Probiotics in inflammatory bowel disease: is it all gut flora modulation? [J].

Ghosh, S ;

van Heel, D ;

Playford, RJ .

GUT, 2004, 53 (05) :620-622

[53] Inerences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis [J].

Gophna, Uri ;

Sommerfeld, Katrin ;

Gophna, Sharon ;

Doolittle, W. Ford ;

van Zanten, Sander J. O. Veldhuyzen .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (11) :4136-4141

[54] Delay of the first onset of pouchitis by oral intake of the Probiotic strain Lactobacillus rhamnosus GG [J].

Gosselink, MP ;

Schouten, WR ;

van Lieshout, LMC ;

Hop, WCJ ;

Laman, JD ;

Ruseler-Van Embden, JGH .

DISEASES OF THE COLON & RECTUM, 2004, 47 (06) :876-884

[55] Butyrate modulates oxidative stress in the colonic mucosa of healthy humans [J].

Hamer, Henrike M. ;

Jonkers, Daisy M. A. E. ;

Bast, Aalt ;

Vanhoutvin, Steven A. L. W. ;

Fischer, Marc A. J. G. ;

Kodde, Andrea ;

Troost, Freddy J. ;

Venema, Koen ;

Brummer, Robert-Jan M. .

CLINICAL NUTRITION, 2009, 28 (01) :88-93

[56] The role of infection in the aetiology of inflammatory bowel disease [J].

Hansen, Richard ;

Thomson, John M. ;

El-Omar, Emad M. ;

Hold, Georgina L. .

JOURNAL OF GASTROENTEROLOGY, 2010, 45 (03) :266-276

[57]

Hawrelak Jason A, 2004, Altern Med Rev, V9, P180

[58] Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis [J].

Heazlewood, Chad K. ;

Cook, Matthew C. ;

Eri, Rajaraman ;

Price, Gareth R. ;

Tauro, Sharyn B. ;

Taupin, Douglas ;

Thornton, David J. ;

Png, Chin Wen ;

Crockford, Tanya L. ;

Cornall, Richard J. ;

Adams, Rachel ;

Kato, Masato ;

Nelms, Keats A. ;

Hong, Nancy A. ;

Florin, Timothy H. J. ;

Goodnow, Christopher C. ;

McGuckin, Michael A. .

PLOS MEDICINE, 2008, 5 (03) :440-460

[59] Community-Wide Response of the Gut Microbiota to Enteropathogenic Citrobacter rodentium Infection Revealed by Deep Sequencing [J].

Hoffmann, Christian ;

Hill, David A. ;

Minkah, Nana ;

Kirn, Thomas ;

Troy, Amy ;

Artis, David ;

Bushman, Frederic .

INFECTION AND IMMUNITY, 2009, 77 (10) :4668-4678

[60] Immune adaptations that maintain homeostasis with the intestinal microbiota [J].

Hooper, Lora V. ;

Macpherson, Andrew J. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (03) :159-169

← 1 2 3 4 5 6 7 8 9 10 →