Factor V Leiden and FII 20210 testing in thromboembolic disorders

被引：5

作者：

Pajic, Tadej ^{[1
]}

机构：

[1] Univ Med Ctr Ljubljana, Dept Haematol, Div Internal Med, Ljubljana, Slovenia

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2010年 / 48卷

关键词：

Factor V Leiden; FII; 20210; quantitative real-time PCR; thromboembolic disorders; ACTIVATED PROTEIN-C; REAL-TIME PCR; POOR ANTICOAGULANT RESPONSE; VENOUS THROMBOEMBOLISM; PROTHROMBIN GENE; APC-RESISTANCE; INHERITED RESISTANCE; MULTIPLEX PCR; 3-UNTRANSLATED REGION; MOLECULAR-MECHANISMS;

D O I：

10.1515/CCLM.2010.372

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection are very important in order to define the increased relative risk for venous thromboembolism in selected patients. Use of DNA-based methods to detect both mutations has become widely available in clinical diagnostic laboratories, including fluorescence-based quantitative real-time PCR (qPCR). The latter is a rapid, simple, robust and reliable method to identify genotypes of interest. There are several chemistries used for qPCR; this article describes their principles and applicability for Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection. Clin Chem Lab Med 2010;48:S79-87.

引用

页码：S79 / S87

页数：9

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