Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte

被引：9
作者：
Ghanem, Murooj [1 ]
Lewis, Gary F. [2 ,4 ]
Xiao, Changting [1 ,3 ]
机构：
[1] Univ Saskatchewan, Coll Med, Dept Anat Physiol & Pharmacol, Saskatoon, SK, Canada
[2] Univ Toronto, Dept Med & Physiol, Toronto, ON, Canada
[3] Univ Saskatchewan, Coll Med, Dept Anat Physiol & Pharmacol, 107 Wiggins Rd, Saskatoon, SK, Canada
[4] Univ Hlth Network, Toronto, ON, Canada
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2022年 / 1867卷 / 10期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Intestine; Triacylglycerol; Cytoplasmic lipid droplet; Enterocyte; HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; DIET-INDUCED OBESITY; FAT-ABSORPTION; PROTECTS MICE; ANIMAL-MODEL; ACYL-COA; TARGETED DISRUPTION; INSULIN-RESISTANCE; CHOLESTERYL ESTER;
D O I：
10.1016/j.bbalip.2022.159197
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy ho-meostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] Role of intestinal probiotics in the modulation of lipid metabolism: implications for therapeutic treatments
    Song, Xiaoran
    Liu, Yanan
    Zhang, Xin
    Weng, Peifang
    Zhang, Ruilin
    Wu, Zufang
    FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (05) : 1439 - 1449
  • [42] From Genetic Findings to new Intestinal Molecular Targets in Lipid Metabolism
    Le May, Cedric
    Ducheix, Simon
    Cariou, Bertrand
    Rimbert, Antoine
    CURRENT ATHEROSCLEROSIS REPORTS, 2024, 27 (01)
  • [43] Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming
    Jelenik, Tomas
    Kodde, Andrea
    Pesta, Dominik
    Phielix, Esther
    Oosting, Annemarie
    Rohbeck, Elisabeth
    Dewidar, Bedair
    Mastrototaro, Lucia
    Trenkamp, Sandra
    Keijer, Jaap
    van der Beek, Eline M.
    Roden, Michael
    PHARMACOLOGICAL RESEARCH, 2022, 179
  • [44] Effects of Enterococcus faecalis Supplementation on Growth Performance, Hepatic Lipid Metabolism, and mRNA Expression of Lipid Metabolism Genes and Intestinal Flora in Geese
    Sun, Siyu
    Zhao, Yujie
    Pang, Zhen
    Wan, Baoxia
    Wang, Jiaqi
    Wu, Zhenyu
    Wang, Qiuju
    ANIMALS, 2025, 15 (02):
  • [45] Glucagon-like peptide-2 mobilization of intestinal lipid does not require canonical enterocyte chylomicron synthetic machinery
    Syed-Abdul, Majid M.
    Stahel, Priska
    Tian, Lili
    Xiao, Changting
    Nahmias, Avital
    Lewis, Gary F.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 1867 (09):
  • [46] Fucosylated chondroitin sulfate alleviates diet-induced obesity by modulating intestinal lipid metabolism and colonic microflora
    Li, Shan
    Guo, Ronghua
    Gao, Xiang
    Wang, Yin
    Wen, Jiaxin
    Zhao, Ting
    Guo, Xiaofei
    Li, Junhui
    Chen, Shiguo
    Li, Duo
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 283
  • [47] Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
    Watanabe, Yoshiyuki
    Fujisaka, Shiho
    Morinaga, Yoshitomo
    Watanabe, Shiro
    Nawaz, Allah
    Hatta, Hideki
    Kado, Tomonobu
    Nishimura, Ayumi
    Bilal, Muhammad
    Aslam, Muhammad Rahil
    Honda, Keiko
    Nakagawa, Yoshimi
    Softic, Samir
    Hirabayashi, Kenichi
    Nakagawa, Takashi
    Nagai, Yoshinori
    Tobe, Kazuyuki
    MOLECULAR METABOLISM, 2023, 77
  • [48] A New Fluorescence-Based Method Identifies Protein Phosphatases Regulating Lipid Droplet Metabolism
    Bozaquel-Morais, Bruno L.
    Madeira, Juliana B.
    Maya-Monteiro, Clarissa M.
    Masuda, Claudio A.
    Montero-Lomeli, Monica
    PLOS ONE, 2010, 5 (10):
  • [49] The recent advances of glucosinolates and their metabolites: Metabolism, physiological functions and potential application strategies
    Wu, Jiaying
    Cui, Shumao
    Liu, Junsheng
    Tang, Xin
    Zhao, Jianxin
    Zhang, Hao
    Mao, Bingyong
    Chen, Wei
    CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2023, 63 (20) : 4217 - 4234
  • [50] 15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism
    Weibel, Ginny L.
    Joshi, Michelle R.
    Wei, Cong
    Bates, Sandra R.
    Blair, Ian A.
    Rothblat, George H.
    JOURNAL OF LIPID RESEARCH, 2009, 50 (12) : 2371 - 2376
12345