Serotype Distribution and Susceptibility of Streptococcus pneumoniae Isolates from Pleural Fluid in Spain from 1997 to 2008

被引：8

作者：

Fenoll, A. ^{[2
]}

Aguilar, L. ^{[1
]}

Vicioso, M. D. ^{[2
]}

Gimenez, M. J. ^{[1
]}

Robledo, O. ^{[2
]}

Granizo, J. J. ^{[3
]}

Mendez, C. ^{[4
]}

机构：

[1] Univ Complutense, Sch Med, Dept Microbiol, E-28040 Madrid, Spain

[2] Inst Salud Carlos III, Spanish Reference Pneumococcal Lab, Madrid, Spain

[3] Grana Datos, Madrid, Spain

[4] Pfizer SA, Dept Med, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 12期

关键词：

PNEUMOCOCCAL CONJUGATE VACCINE; PARAPNEUMONIC EMPYEMA; NONVACCINE SEROTYPES; CHILDREN; DISEASE; RESISTANCE; EMERGENCE; IMPACT;

D O I：

10.1128/AAC.00217-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Trends in serotype incidence and susceptibility (1997 to 2008) of Spanish Streptococcus pneumoniae pleural isolates (n = 831) were explored. Penicillin (oral) nonsusceptibility rates and the incidence of 7-valent pneumococcal conjugate vaccine (PCV-7) serotypes showed decreasing trends (R-2 >= 0.600; P <= 0.002). The incidence of serotypes 1 and 19A showed increasing trends (R-2 >= 0.759; P < 0.001), with no trends for serotype 3. Serotypes 19A, 1, and 3 represented 85% of pediatric isolates in 2008. In serotype 19A, the penicillin nonsusceptibility rate was 82.4% in 2008, associated with amoxicillin and cefotaxime nonsusceptibility in 21.4% of isolates. Inclusion of these serotypes in new vaccines offers the broadest coverage.

引用

页码：5387 / 5390

页数：4

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