Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier

被引：40
作者：
Kastin, AJ
Akerstrom, V
Pan, WH
机构：
[1] VA Med Ctr, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA
来源：
MOLECULAR BRAIN RESEARCH | 2003年 / 114卷 / 02期
关键词：
interleukin-10; cytokine; blood-brain barrier; lipophilicity; hydrogen bonding;
D O I：
10.1016/S0169-328X(03)00167-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that I-125-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted. Published by Elsevier Science B.V.
引用
收藏
页码：168 / 171
页数：4
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