Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier

被引：40
作者：
Kastin, AJ
Akerstrom, V
Pan, WH
机构：
[1] VA Med Ctr, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA
来源：
MOLECULAR BRAIN RESEARCH | 2003年 / 114卷 / 02期
关键词：
interleukin-10; cytokine; blood-brain barrier; lipophilicity; hydrogen bonding;
D O I：
10.1016/S0169-328X(03)00167-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that I-125-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted. Published by Elsevier Science B.V.
引用
收藏
页码：168 / 171
页数：4
相关论文
共 50 条
  • [31] Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia
    Beáta Barabási
    Lilla Barna
    Ana Raquel Santa-Maria
    András Harazin
    Réka Molnár
    András Kincses
    Judit P. Vigh
    Brigitta Dukay
    Miklós Sántha
    Melinda E. Tóth
    Fruzsina R. Walter
    Mária A. Deli
    Zsófia Hoyk
    Fluids and Barriers of the CNS, 20
  • [32] Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability
    Winkler, Ethan A.
    Sengillo, Jesse D.
    Bell, Robert D.
    Wang, Joseph
    Zlokovic, Berislav V.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (10) : 1841 - 1852
  • [33] Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS
    Waters, Sarah
    Swanson, Molly E., V
    Dieriks, Birger, V
    Zhang, Yibin B.
    Grimsey, Natasha L.
    Murray, Helen C.
    Turner, Clinton
    Waldvogel, Henry J.
    Faull, Richard L. M.
    An, Jiyan
    Bowser, Robert
    Curtis, Maurice A.
    Dragunow, Mike
    Scotter, Emma
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2021, 9 (01)
  • [34] The Blood-Brain Barrier
    Gultur, Sefa
    Imir, Gonca
    Tuncer, Ersin
    ERCIYES MEDICAL JOURNAL, 2007, 29 (02) : 147 - 154
  • [35] Protection of the Blood-Brain Barrier as a Therapeutic Strategy for Brain Damage
    Michinaga, Shotaro
    Koyama, Yutaka
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017, 40 (05) : 569 - 575
  • [36] The Blood-Brain Barrier
    Dyrna, Felix
    Hanske, Sophie
    Krueger, Martin
    Bechmann, Ingo
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2013, 8 (04) : 763 - 773
  • [37] The blood-brain barrier
    Dingezweni, S.
    SOUTHERN AFRICAN JOURNAL OF ANAESTHESIA AND ANALGESIA, 2020, 26 (06) : S32 - S34
  • [38] Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
    Luigi Aloe
    Patrizia Bianchi
    Alberto De Bellis
    Marzia Soligo
    Maria Luisa Rocco
    Neural Regeneration Research, 2014, 9 (10) : 1025 - 1030
  • [39] The Blood-Brain Barrier
    Felix Dyrna
    Sophie Hanske
    Martin Krueger
    Ingo Bechmann
    Journal of Neuroimmune Pharmacology, 2013, 8 : 763 - 773
  • [40] Nanoparticle-Mediated Drug Delivery: Blood-Brain Barrier as the Main Obstacle to Treating Infectious Diseases in CNS
    Cavalcanti Gondim, Brenna Louise
    Catarino, Jonatas da Silva
    Dias de Sousa, Marlos Aureliano
    Silva, Mariana de Oliveira
    Lemes, Marcela Rezende
    de Carvalho-Costa, Tamires Marielem
    de Lima Nascimento, Tatiana Rita
    Machado, Juliana Reis
    Rodrigues, Virmondes
    Freire Oliveira, Carlo Jose
    Cancado Castellano, Lucio Roberto
    da Silva, Marcos Vinicius
    CURRENT PHARMACEUTICAL DESIGN, 2019, 25 (37) : 3983 - 3996
12345