Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier

被引：40
|
作者：
Kastin, AJ
Akerstrom, V
Pan, WH
机构：
[1] VA Med Ctr, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA
来源：
MOLECULAR BRAIN RESEARCH | 2003年 / 114卷 / 02期
关键词：
interleukin-10; cytokine; blood-brain barrier; lipophilicity; hydrogen bonding;
D O I：
10.1016/S0169-328X(03)00167-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that I-125-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted. Published by Elsevier Science B.V.
引用
收藏
页码：168 / 171
页数：4
相关论文
共 50 条
  • [1] Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitromodels of the rat blood-brain barrier and blood-spinal cord barrier
    P Marc D Watson
    Judy C Paterson
    George Thom
    Ulrika Ginman
    Stefan Lundquist
    Carl I Webster
    BMC Neuroscience, 14
  • [2] Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier
    Watson, P. Marc D.
    Paterson, Judy C.
    Thom, George
    Ginman, Ulrika
    Lundquist, Stefan
    Webster, Carl I.
    BMC NEUROSCIENCE, 2013, 14
  • [3] Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    Garbuzova-Davis, Svitlana
    Haller, Edward
    Saporta, Samuel
    Kolomey, Irina
    Nicosia, Santo V.
    Sanberg, Paul R.
    BRAIN RESEARCH, 2007, 1157 : 126 - 137
  • [4] Aging disrupts blood-brain and blood-spinal cord barrier homeostasis, but does not increase paracellular permeability
    Cummins, Mitchell J.
    Cresswell, Ethan T.
    Bevege, Renee J.
    Smith, Doug W.
    GEROSCIENCE, 2025, 47 (01) : 263 - 285
  • [5] The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis
    Huang, X. N.
    Fu, J.
    Wang, W. Z.
    JOURNAL OF NEUROIMMUNOLOGY, 2011, 239 (1-2) : 61 - 67
  • [6] Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood-brain barrier in hypertriglyceridemia
    Barabasi, Beata
    Barna, Lilla
    Santa-Maria, Ana Raquel
    Harazin, Andras
    Molnar, Reka
    Kincses, Andras
    Vigh, Judit P.
    Dukay, Brigitta
    Santha, Miklos
    Toth, Melinda E.
    Walter, Fruzsina R.
    Deli, Maria A.
    Hoyk, Zsofia
    FLUIDS AND BARRIERS OF THE CNS, 2023, 20 (01)
  • [7] Altered blood-brain barrier and blood-spinal cord barrier dynamics in amyotrophic lateral sclerosis: Impact on medication efficacy and safety
    Pan, Yijun
    Nicolazzo, Joseph A.
    BRITISH JOURNAL OF PHARMACOLOGY, 2022, 179 (11) : 2577 - 2588
  • [8] Effect of cardiac arrest on brain weight and the permeability of the blood-brain and blood-spinal cord barrier to albumin and tumor necrosis factor-α
    Mizushima, H
    Banks, WA
    Dohi, K
    Shioda, S
    Matsumoto, K
    LIFE SCIENCES, 1999, 65 (20) : 2127 - 2134
  • [9] Penetration of neurotrophins and cytokines across the blood-brain blood spinal cord barrier
    Pan, WH
    Kastin, AJ
    ADVANCED DRUG DELIVERY REVIEWS, 1999, 36 (2-3) : 291 - 298
  • [10] Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model
    Lin, Ronggui
    Chen, Fei
    Wen, Shi
    Teng, Tianhong
    Pan, Yu
    Huang, Heguang
    JOURNAL OF INFLAMMATION-LONDON, 2018, 15
12345