Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

被引：40

作者：

Campbell, Jeffrey D. ^{[1
]}

Burnett, Arthur L. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Dept Urol, Baltimore, MD 21287 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 08期

关键词：

erectile dysfunction; cavernous nerve injury; regenerative medicine; neuroprotection; IMMUNOSUPPRESSANT FK506 INCREASES; ENDOTHELIAL GROWTH-FACTOR; VECTOR-MEDIATED DELIVERY; STEM-CELL THERAPY; RADICAL PROSTATECTOMY; NEUROTROPHIC FACTOR; SONIC HEDGEHOG; NITRIC-OXIDE; RAT MODEL; NEUROVASCULAR BUNDLE;

D O I：

10.3390/ijms18081794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review.

引用

页数：17

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