Extrafollicular antibody responses

被引：456

作者：

MacLennan, ICM ^{[1
]}

Toellner, KM ^{[1
]}

Cunningham, AF ^{[1
]}

Serre, K ^{[1
]}

Sze, DMY ^{[1
]}

Zúñiga, E ^{[1
]}

Cook, MC ^{[1
]}

Vinuesa, CG ^{[1
]}

机构：

[1] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGICAL REVIEWS | 2003年 / 194卷 / 01期

关键词：

MEMORY B-CELLS; CLASS SWITCH RECOMBINATION; CDK INHIBITOR P18(INK4C); ANTIGEN-DRIVEN SELECTION; PRIMARY IMMUNE-RESPONSE; SPLENIC MARGINAL ZONE; STIMULATORY FACTOR-I; LIVED PLASMA-CELLS; DENDRITIC CELLS; TERMINAL DIFFERENTIATION;

D O I：

10.1034/j.1600-065X.2003.00058.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naive and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.

引用

页码：8 / 18

页数：11

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