Iron Oxide Nanoparticle-Incorporated Polymeric Nanocomposites Composed of Poly(DL-lactide-co-glycolide)/Poly(ethylene gycol) Block Copolymer for Magnetic Responsive Drug Delivery Against Tumor

The aim of this study is to fabricate iron oxide nanoparticle-incorporated nanocomposites using poly(DL-lactide-co-glycolide)/poly(ethylene glycol) block copolymer for magnetic-responsive cancer drug targeting. Doxorubicin hydrochloride and iron oxide magnetic nanoparticle incorporated polymeric nanocomposites were prepared by water-in oil-in water double emulsion method. Polymeric nanocomposites have small particle sizes around 200 nm. Morphological observation confirmed that polymeric nanopacomposites have spherical shapes and iron oxide magnetic nanoparticles were incorporated in the polymeric nanocomposites. At in vitro cell culture experiment, polymeric nanocomposites showed magnetic-responsiveness, i.e., polymeric nanocomposites were specifically concentrated in the field of external magnetic area and killed the cancer cells. Furthermore, polymeric nanocomposites also responded to external magnetic stimulus in vivo tumor xenograft model. We suggest magnetism-responsive polymeric nanocomposites as a promising vehicle for drug targeting.