High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815

被引：2
作者：
Galmozzi, E. [1 ]
Facchetti, F. [1 ]
Perbellini, R. [1 ]
Aghemo, A. [1 ]
机构：
[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol & Hepatol, Milan, Italy
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 11期
关键词：
hepatitis C virus; high-resolution melting; IFNL4; IL28B; RT-PCR; PEGYLATED INTERFERON-ALPHA; HEPATITIS-C; SPONTANEOUS CLEARANCE; GENETIC-VARIATION; IL28B; POLYMORPHISM; ASSOCIATION; RIBAVIRIN; THERAPY; ALLELE;
D O I：
10.1111/1469-0691.12637
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Interferon-4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high-resolution melting genotyping assay using 193 patients with chronic hepatitis C.
引用
收藏
页码：O936 / O938
页数：3
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