Primary pericardial synovial sarcoma confirmed by molecular genetic studies - A case report

被引：12

作者：

Hing, Sandra N. ^{[1
]}

Marshall, Lynley ^{[1
]}

Al-Saadi, Reem ^{[1
]}

Hargrave, Darren ^{[1
]}

机构：

[1] Royal Marsden NHS Fdn Trust, Sect Paediat Oncol, Sutton SM2 5PT, Surrey, England

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2007年 / 29卷 / 07期

关键词：

synovial sarcoma; SYT-SSX translocation; molecular genetics; POLYMERASE CHAIN-REACTION; FUSION GENE; SYT-SSX; TRANSLOCATION; SYT-SSX4;

D O I：

10.1097/MPH.0b013e3180640d2e

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary pericardial synovial sarcoma is an extremely rare tumor. The awkward tumor site and clinical features associated with quite advanced disease at presentation make obtaining adequate biopsy material challenging. Ambiguous histologic features may also make diagnosis difficult. We present a case of a 15-year-old patient with an original diagnosis of a spindle cell thymoma. After definitive surgery the diagnosis was amended to a primary pericardial synovial sarcoma. Molecular confirmation of the SYT-SSX fusion gene was critical in reaching an accurate diagnosis. This highlights the necessity for routine molecular genetic studies, so that patient therapy can be directed accordingly.

引用

页码：492 / 495

页数：4

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