Targeting T regulatory cells in autoimmune diseases

被引：0

作者：

Toubi, Elias ^{[1
,2
]}

机构：

[1] Bnai Zion Med Ctr, Div Clin Immunol & Allergy, IL-33394 Haifa, Israel

[2] Technion Israel Inst Technol, Rappaport Fac Med, IL-33394 Haifa, Israel

来源：

ISRAEL MEDICAL ASSOCIATION JOURNAL | 2008年 / 10卷 / 01期

关键词：

T regulatory cells; autoimmune diseases; rheumatoid arthritis; systemic lupus erythematosus;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Among the several mechanisms that play a role in maintaining peripheral self-tolerance is the existence of a unique CD4(+)CD25(+) population of naturally occurring regulatory T cells, which actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve the course of autoimmune diseases.

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页码：73 / 76

页数：4

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