Transfer active ester condensation: A novel technique for peptide segment coupling

被引：27

作者：

Wang, P

Layfield, R

Landon, M

Mayer, RJ

Ramage, R

机构：

[1] Univ Edinburgh, Dept Chem, Edinburgh Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ Nottingham, Sch Med, Queens Med Ctr, Dept Biochem, Nottingham NG7 2UH, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

基金：

英国医学研究理事会;

关键词：

peptides; active esters; segment coupling;

D O I：

10.1016/S0040-4039(98)02002-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide azides can be transformed into the corresponding active esters with HOCt or HOAt, then reacted with another peptide segment to obtain the coupled product. Besides maintaining the advantages of the azide method, this transfer active ester condensation technique affords more efficient segment coupling. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8711 / 8714

页数：4