Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity

被引：19

作者：

Park, Hyun Young ^{[1
]}

Kwon, Soon Bae ^{[2
]}

Heo, Nam Kee ^{[2
]}

Chun, Wan Joo ^{[3
]}

Kim, Myong Jo ^{[4
]}

Kwon, Yong Soo ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

[2] GARES, Special Crops Expt Stat, Chunchon 200150, South Korea

[3] Kangwon Natl Univ, Coll Med, Chunchon 200701, South Korea

[4] Kangwon Natl Univ, Oriental Bioherb Res Inst, Chunchon 200701, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2011年 / 54卷 / 02期

关键词：

Angelica gigas; C-13-nuclear magnetic resonance; chromone; coumarins; diabetic complications; 3'-hydroxyxantyltein; inhibitory activity; rat lens aldose reductase; stem; DIABETIC COMPLICATIONS; FURANOCOUMARINS; COUMARINS; DAHURICA; ROOT; ACETYLCHOLINESTERASE; AGGREGATION; ACTIVATION; COMPOUND; CELLS;

D O I：

10.3839/jksabc.2011.032

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Eleven compounds were isolated from the stem of Angelica gigas. On the basis of spectral data, these compounds were identified as isoimperatorin (1), 7-methoxy-5-prenyloxycoumarin (2), imperatorin (3), decursin (4), bergapten (5), psoralen (6), xanthotoxin (7), p-hydroxyphenethyl trans-ferulate (8), visamminol (9), scopoletin (10), and 3'-hydroxyxanthyletin (11). All isolates were evaluated in vitro for their inhibitory activities on the rat lens aldose reducatase. Tested compounds (1-11) exhibited inhibitory activities against rat lens aldose reductase with IC50 values ranging from 2.59 to 191.91 mu M.

引用

页码：194 / 199

页数：6

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