Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

被引:1
作者
James, Rachel [1 ]
Dimopoulou, Olympia [1 ,2 ]
Martin, Richard M. [1 ,2 ]
Perks, Claire M. [3 ]
Kelly, Claire [1 ]
Mathias, Louise [1 ]
Brugger, Stefan [1 ]
Higgins, Julian P. T. [1 ,2 ]
Lewis, Sarah J. [1 ,2 ]
机构
[1] Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol BS8 2BN, Avon, England
[2] Univ Bristol, Integrat Epidemiol Unit, Med Res Council, Bristol BS8 2BN, Avon, England
[3] Univ Bristol, Bristol Med Sch, Translat Hlth Sci, IGF & Metab Endocrinol Grp, Bristol BS10 5NB, Avon, England
关键词
body fatness; prostate cancer; biomarker; insulin; insulin signalling; mechanisms; systematic review; INDUCED WEIGHT-LOSS; DIABETES-MELLITUS; SERUM-INSULIN; C-PEPTIDE; RESISTANCE; OBESITY; EPIDEMIOLOGY; METAANALYSIS; ASSOCIATION; MORTALITY;
D O I
10.3390/metabo11110726
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of insulin signalling have been positively associated with PCa risk. We carried out a two-pronged systematic review of (a) the effect of reducing body fatness on insulin biomarker levels and (b) the effect of insulin biomarkers on PCa risk, to determine whether a reduction in body fatness could reduce PCa risk via effects on the insulin signalling pathway. We identified seven eligible randomised controlled trials of interventions designed to reduce body fatness which measured insulin biomarkers as an outcome, and six eligible prospective observational studies of insulin biomarkers and PCa risk. We found some evidence that a reduction in body fatness improved insulin sensitivity although our confidence in this evidence was low based on GRADE (Grading of Recommendations, Assessment, Development and Evaluations). We were unable to reach any conclusions on the effect of insulin sensitivity on PCa risk from the few studies included in our systematic review. A reduction in body fatness may reduce PCa risk via insulin signalling, but more high-quality evidence is needed before any conclusions can be reached regarding PCa.
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页数:21
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