Acute-on-Chronic Liver Failure in Cirrhosis

被引：15
作者：
Gambino, Carmine [1 ]
Piano, Salvatore [1 ]
Angeli, Paolo [1 ]
机构：
[1] Univ Padua, Dept Med, UIMH, I-35128 Padua, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 19期
关键词：
acute-on-chronic liver failure (ACLF); cirrhosis; liver transplantation (LT); TERLIPRESSIN PLUS ALBUMIN; ASIAN-PACIFIC ASSOCIATION; CONSENSUS RECOMMENDATIONS; HEPATORENAL-SYNDROME; IMPROVES SURVIVAL; CLINICAL-COURSE; MANAGEMENT; TRANSPLANTATION; THERAPY; PREDICT;
D O I：
10.3390/jcm10194406
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculiarity of each one, every definition proposed for ACLF recognizes it as a proper clinical entity. In this paper, we provide an overview of the diagnostic criteria proposed by the different scientific societies and the clinical characteristics of the syndrome. Established and experimental treatments are also described. Among the former, the most relevant are directed to support organ failures, treat precipitating factors and carry out early assessment for liver transplantation (LT). Further studies are needed to better clarify pathophysiology of the syndrome and discover new therapies
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页数：11
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