HP-NAP of Helicobacter pylori: The Power of the Immunomodulation

被引：19
作者：
Codolo, Gaia [1 ]
Coletta, Sara [1 ]
D'Elios, Mario Milco [2 ]
de Bernard, Marina [1 ]
机构：
[1] Univ Padua, Dept Biol, Padua, Italy
[2] Univ Firenze, Dept Expt & Clin Med, Florence, Italy
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
HP-NAP; Helicobacter pylori; inflammation; allergy; cancer; therapy; NEUTROPHIL-ACTIVATING PROTEIN; RECOMBINANT FUSION PROTEIN; HUMAN GASTRIC-MUCOSA; DNA-BINDING PROTEIN; TREPONEMA-PALLIDUM; BACILLUS-SUBTILIS; INFLAMMATION; EXPRESSION; ANTITUMOR; FERRITIN;
D O I：
10.3389/fimmu.2022.944139
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The miniferritin HP-NAP of Helicobacter pylori was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the H. pylori infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy.
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页数：7
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