Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer

被引：54

作者：

Kasashima, Hiroaki ^{[1
]}

Yashiro, Masakazu ^{[1
,2
]}

Okuno, Tomohisa ^{[1
]}

Miki, Yuichiro ^{[1
]}

Kitayama, Kisyu ^{[1
]}

Masuda, Go ^{[1
]}

Kinoshita, Haruhito ^{[1
]}

Morisaki, Tamami ^{[1
]}

Fukuoka, Tatsunari ^{[1
]}

Hasegawa, Tsuyoshi ^{[1
]}

Sakurai, Katsunobu ^{[1
]}

Toyokawa, Takahiro ^{[1
]}

Kubo, Naoshi ^{[1
]}

Tanaka, Hiroaki ^{[1
]}

Muguruma, Kazuya ^{[1
]}

Hirakawa, Kosei ^{[1
]}

Ohira, Masaichi ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Osaka, Japan

[2] Osaka City Univ, Grad Sch Med, Mol Oncol & Therapeut, Osaka, Japan

来源：

DIGESTION | 2018年 / 98卷 / 04期

关键词：

Gastric cancer; Lysyl oxidase like 1; Lysyl oxidase like 3; Lysyl oxidase like 4; Transforming growth factor 1; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; TGF-BETA; TUMOR PROGRESSION; METASTATIC MODEL; CROSS-LINKING; UP-REGULATION; NUDE-MICE; LOXL2; CELLS;

D O I：

10.1159/000489558

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Lysyl oxidase (LOX) family members play a key role in modifying the primary tumor microenvironment by crosslinking collagens and elastin in the extracellular matrix. The aim of this study was to analyze the LOX-like (LOXL)1, LOXL3, and LOXL4 expressions in gastric cancer tissue by immunohistochemical staining. Methods: The correlations between the clinicopathological features of 597 primary gastric carcinomas and LOX family members - LOXL1, LOXL3, and LOXL4 - were investigated by immunohistochemical studies. The effect of the transforming growth factor 1 (TGF1) on the expressions of LOXL1, LOXL3, and LOXL4 in gastric cancer was examined using diffuse-type gastric cancer cell lines in vitro. Results: The expressions of LOXL1, LOXL3, and LOXL4 were correlated with T invasion, lymph node metastasis, and lymphatic and venous invasion. LOXL1 expression was associated with histological intestinal-type and expanding growth patterns. The overall survival of patients with LOXL1-, LOXL3-, or LOXL4-positive cancer was poorer than those with negative cancer. LOXL3 and LOXL4 mRNA expressions were significantly high in diffuse-type gastric cancer cells with high invasion ability. TGF decreased the LOXL1 expression and increased LOXL3 and LOXL4 expression. Conclusion: LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer.

引用

页码：238 / 248

页数：11

共 47 条

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