Relationship between Cytochrome P450 2E1 Gene Polymorphism and Susceptibility of Low Birth Weight Infants

The purpose of this study is to investigate the relationship between cytochrome P450 2E1 (CYP2E1) RsaI/PstI and DraI single gene polymorphism (SNP) and low birth weight infants (LBW) of Chinese population. The researchers detected CYP2E1 RsaI/PstI and DraI SNPs by real-time PCR cycling and HRM analysis in 461 premature delivery and 461 healthy pregnant women. This paper found that RsaI/PstI C2C2 was statistically significantly correlation with increased risk of LBW (Odds ratios=0.66,95% CI: 0.44-0.98, P = 0.04) and (Odds ratios = 0.75, 95% CI: 0.56-0.99, P=0.04) for C2C2, compared with C1C1 and C1C1 + C1C2, respectively. When CYP2E1 RsaI/PstI and DraI SNPs combine, the risk of low birth weight infants was increased in individuals with both DraI TT and RsaI/PstI C2C2 genotypes (Odds ratios=0.59, 95% CI=0.36-0.97). The current study demonstrates CYP2E1 RsaI/PstI polymorphism is significantly related to LBW and the interaction between the RsaI/PstI and DraI polymorphisms has a significant impact on LBW.