Synthesis of Dialkyl-Substituted Monofluoroalkenes via Palladium-Catalyzed Cross-Coupling of Alkyl Carbagermatranes

被引：24

作者：

Wang, Chao ^{[1
]}

Liu, Yu-Chao ^{[1
]}

Xu, Meng-Yu ^{[1
]}

Xiao, Bin ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 12期

基金：

中国博士后科学基金;

关键词：

STEREOSELECTIVE-SYNTHESIS; GEM-DIFLUOROALKENES; DESIGN; FLUOROOLEFINS; INHIBITORS; SECONDARY; ESTERS; ACIDS;

D O I：

10.1021/acs.orglett.1c01289

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented cross-coupling reaction of alkyl carbagermatranes with bromofluoroolefins to deliver dialkyl-substituted monofluoroalkenes was achieved. This cross-coupling reaction was performed under base/additive-free conditions with excellent functional group tolerance, therefore offering an opportunity for challenging dialkyl-substituted monofluoroalkenes. The preparation of bioactive agent analogues including an antitubercular agent mimic and a COX-2 inhibitor analogue and the late-stage fluoroalkenylation of drug-molecule derivatives proved the utility of this strategy.

引用

页码：4593 / 4597

页数：5

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