Accelerating the Bone Healing Process by the Intervention of the Platelet Growth Factors Impregnated in Collagen An experimental and theoretical mathematical model

被引：0

作者：

Susanu, Sidonia ^{[1
]}

Popescu, Mara ^{[1
]}

Caba, Bogdan ^{[1
]}

Plamadeala, Petru ^{[2
]}

Moraru, Andreea ^{[3
]}

Costin, Dan ^{[3
]}

Gavrilut, Gabriel ^{[4
]}

Agop, Maricel ^{[5
,6
]}

Cioca, Gabriela ^{[7
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Dept Plast & Reconstruct Surg, 16 Univ Str, Iasi 700115, Romania

[2] Emergency Hosp Children, Dept Anat Pathol, 62 Vasile Lupu Str, Iasi 700309, Romania

[3] Grigore T Popa Univ Med & Pharm, Dept Ophthalmol, 16 Univ Str, Iasi 700115, Romania

[4] Alexandru Ioan Cuza Univ, Dept Theoret Phys, Fac Phys, 11 Carol I Blvd, Iasi 700506, Romania

[5] Gheorghe Asachi Tech Univ Iasi, Fac Machine Mfg & Ind Management, Dept Phys, 73 D Mangeron Blvd, Iasi 700050, Romania

[6] Romanian Sci Acad, 54 Splaiul Independentei Blvd, Bucharest 050094, Romania

[7] Lucian Blaga Univ Sibiu, Periclin Dept, Fac Med, 2B Lucian Blaga Str, Sibiu 550024, Romania

来源：

MATERIALE PLASTICE | 2019年 / 56卷 / 04期

关键词：

bone; collagen; multifractal; EPSILON((INFINITY)) SPACE-TIME; SCALE RELATIVITY THEORY; DRUG-RELEASE PROCESSES; RICH CONCENTRATE; HYDRODYNAMIC MODEL; NONUNIONS; SURGERY;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A bone defect with standard dimensions and localization is produced. Inside this defect a polymer (collagen sponge) impregnated with growing factors, i.e. bone morphogenetic protein - BMP, is introduced. For the witness lot, the same defect is produced, in which the same polymer is introduced, but without any growing factors. It is found that the growing factor not only remains at the initial site, but also has effect on the bone regeneration process. A mathematical model is constructed using a field theory of multifractal type based on the spontaneous symmetry breaking mechanism to exploit such dynamics in biostructures. This mechanism contains all the informational "ingredients": the multivalent logic based multifractal bit, the algorithm based networks through spatial cnoidal modes of oscilation, etc. In such context, the evolution of all biostructures, through a mechanism that mimics a 3D biological printer, can become operational.

引用

页码：973 / 979

页数：7