An ultrastructural and molecular perspective of the pathological hallmarks of Alzheimer's disease

被引：0
作者：
Sobow, T
机构：
[1] SCH MED,DEPT ONCOL,LABS TUMOR BIOL,LAB ELECTRON MICROSCOPY & NEUROPATHOL,LODZ,POLAND
[2] SCH MED,DEPT PSYCHIAT,PSYCHIAT CLIN 2,LODZ,POLAND
来源：
FOLIA NEUROPATHOLOGICA | 1996年 / 34卷 / 01期
关键词：
Alzheimer's disease; neurofibrillary tangles; amyloid plaques;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An update review of selected issues of the current knowledge of the pathology of Alzheimer's disease, by far the most common cause of human dementia is presented. The molecular basis of the most prominent ultrastructural features of AD including neurofibrillary tangles and the amyloid plaque as well as dystrophic neurites and neuropil threads. The major role of beta APP and its metabolic pathways in the pathogenesis of AD has been strongly pointed out.
引用
收藏
页码：55 / 62
页数：8
相关论文
共 50 条
  • [41] Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease
    Brai, Emanuele
    Raio, Noemi Alina
    Alberi, Lavinia
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2016, 4 : 64
  • [42] Behaviour Hallmarks in Alzheimer's Disease 5xFAD Mouse Model
    Padua, Mafalda Soares
    Guil-Guerrero, Jose L.
    Lopes, Paula Alexandra
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (12)
  • [43] The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
    Liu, Yuqing
    Tan, Yejun
    Zhang, Zheyu
    Yi, Min
    Zhu, Lemei
    Peng, Weijun
    TRANSLATIONAL NEURODEGENERATION, 2024, 13 (01)
  • [44] Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease
    Emanuele Brai
    Noemi Alina Raio
    Lavinia Alberi
    Acta Neuropathologica Communications, 4
  • [45] Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease
    Polidori, M. C.
    Griffiths, H. R.
    Mariani, E.
    Mecocci, P.
    AMINO ACIDS, 2007, 32 (04) : 553 - 559
  • [46] Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease
    Korsak, Magdalena
    Kozyreva, Tatiana
    INTRINSICALLY DISORDERED PROTEINS STUDIED BY NMR SPECTROSCOPY, 2015, 870 : 401 - 421
  • [47] An Insight into Cellular and Molecular Mechanisms Underlying the Pathogenesis of Neurodegeneration in Alzheimer's Disease
    Ratan, Yashumati
    Rajput, Aishwarya
    Maleysm, Sushmita
    Pareek, Aaushi
    Jain, Vivek
    Pareek, Ashutosh
    Kaur, Ranjeet
    Singh, Gurjit
    BIOMEDICINES, 2023, 11 (05)
  • [48] Pathological mechanisms and therapeutic strategies for Alzheimer's disease
    Ju, Yaojun
    Tam, Kin Yip
    NEURAL REGENERATION RESEARCH, 2022, 17 (03) : 543 - +
  • [49] Pathological mechanisms and therapeutic strategies for Alzheimer's disease
    Yaojun Ju
    Kin Yip Tam
    Neural Regeneration Research, 2022, 17 (03) : 543 - 549
  • [50] Pathological Impacts of Chronic Hypoxia on Alzheimer's Disease
    Zhang, Feng
    Niu, Long
    Li, Song
    Le, Weidong
    ACS CHEMICAL NEUROSCIENCE, 2019, 10 (02): : 902 - +
12345