An ultrastructural and molecular perspective of the pathological hallmarks of Alzheimer's disease

被引：0
作者：
Sobow, T
机构：
[1] SCH MED,DEPT ONCOL,LABS TUMOR BIOL,LAB ELECTRON MICROSCOPY & NEUROPATHOL,LODZ,POLAND
[2] SCH MED,DEPT PSYCHIAT,PSYCHIAT CLIN 2,LODZ,POLAND
来源：
FOLIA NEUROPATHOLOGICA | 1996年 / 34卷 / 01期
关键词：
Alzheimer's disease; neurofibrillary tangles; amyloid plaques;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An update review of selected issues of the current knowledge of the pathology of Alzheimer's disease, by far the most common cause of human dementia is presented. The molecular basis of the most prominent ultrastructural features of AD including neurofibrillary tangles and the amyloid plaque as well as dystrophic neurites and neuropil threads. The major role of beta APP and its metabolic pathways in the pathogenesis of AD has been strongly pointed out.
引用
收藏
页码：55 / 62
页数：8
相关论文
共 50 条
  • [31] Cholesterol and pathological processes in Alzheimer's disease
    Yanagisawa, K
    JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) : 361 - 366
  • [32] Neurobiology and molecular biology of Alzheimer's disease
    DeKosky, ST
    REVISTA DE NEUROLOGIA, 2002, 35 (08) : 752 - 760
  • [33] Does the Interplay Between Aging and Neuroinflammation Modulate Alzheimer's Disease Clinical Phenotypes? A Clinico-Pathological Perspective
    Taipa, Ricardo
    Sousa, Ana Luisa
    Pires, Manuel Melo
    Sousa, Nuno
    JOURNAL OF ALZHEIMERS DISEASE, 2016, 53 (02) : 403 - 417
  • [34] The preclinical phase of the pathological process underlying sporadic Alzheimer's disease
    Braak, Heiko
    Del Tredici, Kelly
    BRAIN, 2015, 138 : 2814 - 2833
  • [35] The pathological process underlying Alzheimer’s disease in individuals under thirty
    Heiko Braak
    Kelly Del Tredici
    Acta Neuropathologica, 2011, 121 : 171 - 181
  • [36] The neuropathological diagnosis of Alzheimer's disease: Clinical-pathological studies
    Hyman, BT
    NEUROBIOLOGY OF AGING, 1997, 18 (04) : S27 - S32
  • [37] A perspective on inflammation in Alzheimer's disease
    Rogers, J
    Shen, Y
    ALZEHEIMER'S DISEASE: A COMPENDIUM OF CURRENT THEORIES, 2000, 924 : 132 - 135
  • [38] The pathological process underlying Alzheimer's disease in individuals under thirty
    Braak, Heiko
    Del Tredici, Kelly
    ACTA NEUROPATHOLOGICA, 2011, 121 (02) : 171 - 181
  • [39] Role of tau protein in Alzheimer's disease: The prime pathological player
    Muralidar, Shibi
    Ambi, Senthil Visaga
    Sekaran, Saravanan
    Thirumalai, Diraviyam
    Palaniappan, Balamurugan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 163 : 1599 - 1617
  • [40] Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective
    Banerjee, Rajashree
    Rai, Arushi
    Iyer, Shreyas M.
    Narwal, Sonia
    Tare, Meghana
    ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2022, 5 (01) : 27 - 37
12345