An ultrastructural and molecular perspective of the pathological hallmarks of Alzheimer's disease

被引：0
作者：
Sobow, T
机构：
[1] SCH MED,DEPT ONCOL,LABS TUMOR BIOL,LAB ELECTRON MICROSCOPY & NEUROPATHOL,LODZ,POLAND
[2] SCH MED,DEPT PSYCHIAT,PSYCHIAT CLIN 2,LODZ,POLAND
来源：
FOLIA NEUROPATHOLOGICA | 1996年 / 34卷 / 01期
关键词：
Alzheimer's disease; neurofibrillary tangles; amyloid plaques;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An update review of selected issues of the current knowledge of the pathology of Alzheimer's disease, by far the most common cause of human dementia is presented. The molecular basis of the most prominent ultrastructural features of AD including neurofibrillary tangles and the amyloid plaque as well as dystrophic neurites and neuropil threads. The major role of beta APP and its metabolic pathways in the pathogenesis of AD has been strongly pointed out.
引用
收藏
页码：55 / 62
页数：8
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