This paper studies the effects of the antibacterial and anti-adhesion properties of self-assembled monolayers (SAMs) on optical parts. Therefore, the experiments in this study prepared several kinds of SAMs, including alkyl and biphenyl spacer chains with different surface terminal groups (-CH3,-COOH) and head groups (-SH). This study reports the growth of eight self-assembled monolayers on optical parts: OTS, ODS, OTS with antibacterial solution, ODS with antibacterial solution, and pure antibacterial solution, with bio-compatibility. Experimental results regarding the contact angle of five self-assembled monolayers show that ODS with antibacterial illustrated the maximum contact angle 103 12 hours after reaction. The solutions of OTS, ODS with antibacterial, OTS with antibacterial, and pure anti-bacterial showed contact angles of 102, 99, 101, and 59 respectively. These results indicate that the antibacterial solution has negligible effects on anti-adhesion property of optical lenses. The results of digital optical microscope system analysis show that in the antibacterial experiment of eight kinds of self-assembled monolayers, the OTS(anti)50% effect cultured for 24 hours achieved the best results, with a growth rate of 12%. The descending order of antibacterial effect is antibacterial 10%>ODS>OTS> antibacterial 50%>ODS(anti)50%>OTS(anti)10%>ODS(anti)10%. In summary, the surface treatment of optical lenses involving OTSanti 50% is the most capable of effectively increasing antifouling and antibacterial functions.