Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations

被引：0
|
作者：
Pawlikowski, M
Gruszka, A
Radek, M
Kunert-Radek, J
机构：
[1] Med Univ Lodz, Inst Endocrinol, Dept Expt Endocrinol & Hormone Diagnost, PL-91425 Lodz, Poland
[2] Med Univ Lodz, Inst Endocrinol, Dept Clin Endocrinol, PL-91425 Lodz, Poland
[3] Med Univ Lodz, Dept Neurosurg & Surg Peripheral Nerves, PL-91425 Lodz, Poland
来源：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2004年 / 42卷 / 04期
关键词：
chromogranin A; pituitary tumors; gonadotropinomas; null cell adenomas;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.
引用
收藏
页码：245 / 247
页数：3
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