Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations

被引：0
|
作者：
Pawlikowski, M
Gruszka, A
Radek, M
Kunert-Radek, J
机构：
[1] Med Univ Lodz, Inst Endocrinol, Dept Expt Endocrinol & Hormone Diagnost, PL-91425 Lodz, Poland
[2] Med Univ Lodz, Inst Endocrinol, Dept Clin Endocrinol, PL-91425 Lodz, Poland
[3] Med Univ Lodz, Dept Neurosurg & Surg Peripheral Nerves, PL-91425 Lodz, Poland
来源：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2004年 / 42卷 / 04期
关键词：
chromogranin A; pituitary tumors; gonadotropinomas; null cell adenomas;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.
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页码：245 / 247
页数：3
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