Two new butanolides from the roots of Litsea acuminata

被引：13

作者：

Tanaka, Hitoshi ^{[1
]}

Takaya, Yoshiaki ^{[1
]}

Toyoda, Junya ^{[1
]}

Yasuda, Tadashi ^{[2
]}

Sato, Masaru ^{[2
]}

Murata, Jin ^{[3
]}

Murata, Hiroko ^{[4
]}

Kaburagi, Koichi ^{[5
]}

Iida, Osamu ^{[5
]}

Sugimura, Koji ^{[5
]}

Sakai, Eiji ^{[6
]}

机构：

[1] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[2] Asahi Univ, Sch Dent, Dept Oral Biol, Gifu 5010296, Japan

[3] Univ Tokyo, Bot Gardens, Grad Sch Sci, Bunkyo Ku, Tokyo 1120001, Japan

[4] Setsunan Univ, Fac Pharmaceut Sci, Hirakata, Osaka 5730101, Japan

[5] Natl Inst Biomed Innovat, Res Ctr Med Plant Resources, Tanegashima Div, Nakatate, Kagoshima 8913604, Japan

[6] Gifu Pharmaceut Univ, Gifu 5028585, Japan

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 11卷

关键词：

Litsea acuminata; Lauraceae; Butanolides; Licunolide A; Licunolide B; Cytotoxicity; ACTINODAPHNE-LONGIFOLIA; LACTONIC COMPOUNDS; LANCIFOLIA; ASSAY;

D O I：

10.1016/j.phytol.2014.11.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new butanolides, licunolides A (1) and B (2), were isolated from the roots of Litsea acuminata, together with three known compounds: isolancifolide (3), longifolin (4), and sesquirose furan (5). The structures of compounds 1 and 2 were determined by spectroscopic studies (IR, MS, 1D and 2D NMR) and chemical evidence. This is the first report of 4-hydroxy-5-methylbutanolides with a C-10-side chain from a natural source. Longifolin (4) and sesquirose furan (5) showed a significant cytotoxicity against HeLa cell lines in vitro. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：32 / 36

页数：5

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