Analyses of Meldonium (Mildronate) from Blood, Dried Blood Spots (DBS), and Urine Suggest Drug Incorporation into Erythrocytes

被引：23
|
作者：
Tretzel, L. [1 ]
Goergens, C. [1 ]
Geyer, H. [1 ,2 ]
Thomas, A. [1 ]
Dib, J. [1 ]
Guddat, S. [1 ]
Pop, V. [3 ]
Schaenzer, W. [1 ]
Thevis, M. [1 ,2 ]
机构：
[1] German Sport Univ Cologne, Ctr Prevent Doping Res, Inst Biochem, Sportpk Muengersdorf 6, D-50933 Cologne, Germany
[2] European Monitoring Ctr Emerging Doping Agents Eu, Cologne, Germany
[3] Natl Antidoping Agcy, Romanian Doping Control Lab, Bvd Basarabia 37-39, Bucharest, Romania
来源：
INTERNATIONAL JOURNAL OF SPORTS MEDICINE | 2016年 / 37卷 / 06期
关键词：
CARNITINE; MS/MS;
D O I：
10.1055/s-0036-1582317
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
引用
收藏
页码：500 / 502
页数：3
相关论文
共 12 条
  • [1] Use of Dried Blood Spots in Drug Development: Pharmacokinetic Considerations
    Rowland, Malcolm
    Emmons, Gary T.
    AAPS JOURNAL, 2010, 12 (03): : 290 - 293
  • [2] Utilization of dried blood spots within drug discovery: modification of a standard DiLab® AccuSampler® to facilitate automatic dried blood spot sampling
    Clark, G. T.
    Giddens, G.
    Burrows, L.
    Strand, C.
    LABORATORY ANIMALS, 2011, 45 (02) : 124 - 126
  • [3] Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots
    Heinig, Katja
    Bucheli, Franz
    Hartenbach, Roswitha
    Gajate-Perez, Almudena
    BIOANALYSIS, 2010, 2 (08) : 1423 - 1435
  • [4] Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry
    Shokry, Engy
    Villanelli, Fabio
    Malvagia, Sabrina
    Rosati, Anna
    Forni, Giulia
    Funghini, Silvia
    Ombrone, Daniela
    Della Bona, Maria
    Guerrini, Renzo
    la Marca, Giancarlo
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 109 : 164 - 170
  • [5] A novel method for quantification of human hemoglobin from dried blood spots by use of tandem mass spectrometry
    Yu, Chaowen
    Zhang, Juan
    Yuan, Zhaojian
    Liu, Hao
    Wang, Xingbin
    Wang, Ming
    Zou, Lin
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2015, 407 (26) : 8121 - 8127
  • [6] Rapid metabolic and newborn screening of thyroxine (T4) from dried blood spots by MS/MS
    Chace, Donald H.
    Singleton, Scott
    DiPerna, James
    Aiello, Mauro
    Foley, Thomas
    CLINICA CHIMICA ACTA, 2009, 403 (1-2) : 178 - 183
  • [7] Evaluation of dried blood spots as an alternative sampling strategy for 5-fluorouracil monitoring: From method development to clinical application
    da Silva, Laura C.
    Grando, Ana P.
    de Baco, Lucas S.
    Hahn, Roberta Z.
    Ferreira Filho, Antonio F.
    Brucker, Natalia
    Linden, Rafael
    Antunes, Marina, V
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 235
  • [8] Comparison of paper spray mass spectrometry analysis of dried blood spots from devices used for in-field collection of clinical samples
    Yannell, Karen E.
    Kesely, Kristina R.
    Huynh Dinh Chien
    Kissinger, Candice B.
    Cooks, R. Graham
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2017, 409 (01) : 121 - 131
  • [9] Comparison of C26:0-carnitine and C26:0-lysophosphatidylcholine as diagnostic markers in dried blood spots from newborns and patients with adrenoleukodystrophy
    Huffnagel, Irene C.
    van de Beek, Malu-Clair
    Showers, Amanda L.
    Orsini, Joseph J.
    Klouwer, Femke C. C.
    Dijkstra, Inge M. E.
    Schielen, Peter C.
    van Lenthe, Henk
    Wanders, Ronald J. A.
    Vaz, Frederic M.
    Morrissey, Mark A.
    Engelen, Marc
    Kemp, Stephan
    MOLECULAR GENETICS AND METABOLISM, 2017, 122 (04) : 209 - 215
  • [10] Direct analysis of dried blood spots by in-line desorption combined with high-resolution chromatography and mass spectrometry for quantification of maple syrup urine disease biomarkers leucine and isoleucine
    Miller, John H.
    Poston, Philip A.
    Karnes, H. Thomas
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 400 (01) : 237 - 244
12